- Tolmetin
- Tolmetin glycinamide
- Tolmetin sodium
- 35711-47-82,5-DIMETHYL-1-PYRIDIN-3-YL-1H-PYRROLE-3-CARBALDEHYDE
- 3571-45-7Ethanaminium,2,2'-[1-(1-methylethyl)-1,2-ethanediyl]bis(4,1-phenyleneoxy)bis[N,N,N-trimethyl-,diiodide (9CI)
- 3571-53-7Estra-1,3,5(10)-triene-3,17-diol(17b)-, 17-undecanoate
- 35715-67-41H-Pyrazole,1-(4-methoxyphenyl)-
- 357166-29-1L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate
- 357166-30-4L-Glutamic acid,N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-,sodium salt, hydrate (2:4:5) (9CI)
- 35716-89-33(2H)-Pyridazinone,6-(dimethylamino)-
- 3571-74-2Thiazole,4,5-dihydro-2-(2-propen-1-ylthio)-
- 35718-03-7Bicyclo[2.2.1]heptan-2-amine,N-(phenylmethyl)-
- 35718-34-4Trihydrogen (2-((4-((6-((4-amino-6-chloro-1,3,5-triazin-2-yl)methylamino)-1-hydroxy-3-sulpho-2-naphthyl)azo)-5-hydroxy-o-tolyl)azo)benzene-1,4-disulphonato(5-))cuprate(3-)
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Cas Database |
| Name |
Tolmetin sodium |
EINECS | 252-687-3 |
| CAS No. | 35711-34-3 | Density | 1.18g/cm3 |
| PSA | 62.13000 | LogP | 0.85690 |
| Solubility | N/A | Melting Point |
155-157oC (DECOMPOSES) |
| Formula | C15H15 N O3 . Na | Boiling Point | 483.2 °C at 760 mmHg |
| Molecular Weight | 279.271 | Flash Point | 246 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, blood pressure depression, eye irritation, hallucinations or distorted perceptions, liver function impairment, shock, spinal cord effects, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Na2O. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (9CI); Sodium1-methyl-5-p-toluoylpyrrole-2-acetate; Sodium tolmetin; Tolectin; Tolmetinsodium; Tolmetin sodium salt |
Article Data | 4 |
Tolmetin sodium Chemical Properties
Empirical Formula of Tolmetin sodium (CAS NO.35711-34-3): C15H14NNaO3
Molecular Weight: 279.2663
EINECS: 252-687-3
Flash Point: 246 °C
Enthalpy of Vaporization: 78.81 kJ/mol
Boiling Point: 483.2 °C at 760 mmHg
Vapour Pressure: 3.79E-10 mmHg at 25 °C
Structure of Tolmetin sodium (CAS NO.35711-34-3):
H-Bond Donor: 0
H-Bond Acceptor: 3
IUPAC Name of Tolmetin sodium (CAS NO.35711-34-3): Sodium 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-].[Na+]
InChI: InChI=1S/C15H15NO3.Na/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;/h3-8H,9H2,1-2H3,(H,17,18);/q;+1/p-1
InChIKey: QGUALMNFRILWRA-UHFFFAOYSA-M
Tolmetin sodium Uses
Tolmetin sodium (CAS NO.35711-34-3) has been used as an antipyretic analgesic.
Tolmetin sodium Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 2520mg/kg/8W- (2520mg/kg) | BLOOD: THROMBOCYTOPENIA | Arthritis and Rheumatism. Vol. 25, Pg. 1144, 1982. |
| dog | LD50 | oral | > 800mg/kg (800mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977. | |
| hamster | LD50 | oral | 1584mg/kg (1584mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977. | |
| human | TDLo | oral | 8mg/kg (8mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: SHOCK | JAMA, Journal of the American Medical Association. Vol. 240, Pg. 246, 1978. |
| man | TDLo | oral | 538mg/kg/61D- (538mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1263, 1980. |
| mouse | LD50 | intraperitoneal | 690mg/kg (690mg/kg) | Drugs in Japan Vol. 6, Pg. 532, 1982. | |
| mouse | LD50 | intravenous | > 622mg/kg (622mg/kg) | Drugs in Japan Vol. 6, Pg. 532, 1982. | |
| mouse | LD50 | oral | 899mg/kg (899mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977. | |
| mouse | LD50 | subcutaneous | 670mg/kg (670mg/kg) | Drugs in Japan Vol. 6, Pg. 532, 1982. | |
| rat | LD50 | intraperitoneal | 770mg/kg (770mg/kg) | Drugs in Japan Vol. 6, Pg. 532, 1982. | |
| rat | LD50 | intravenous | > 724mg/kg (724mg/kg) | Drugs in Japan Vol. 6, Pg. 532, 1982. | |
| rat | LD50 | oral | 914mg/kg (914mg/kg) | Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977. | |
| rat | LD50 | subcutaneous | 1050mg/kg (1050mg/kg) | Drugs in Japan Vol. 6, Pg. 532, 1982. | |
| women | TDLo | oral | 8mg/kg (8mg/kg) | SPINAL CORD: MENINGEAL CHANGES SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LIVER: LIVER FUNCTION TESTS IMPAIRED | JAMA, Journal of the American Medical Association. Vol. 245, Pg. 67, 1981. |
Tolmetin sodium Safety Profile
Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, blood pressure depression, eye irritation, hallucinations or distorted perceptions, liver function impairment, shock, spinal cord effects, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Na2O.
Tolmetin sodium Specification
Tolmetin sodium ,its cas register number is 35711-34-3. It also can be called Natrium-{1-methyl-5-[(4-methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetat ; 1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (1:1) ; Tolectin and Sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate .
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