Alkoxycarbonylation reactions involve the addition of a carbonyl group (C=O) and an alkoxy group (-OR) to a substrate. Palladium-catalyzed alkoxycarbonylation of β-lactam vinyl triflates is a versatile method for the synthesis of β-lactams bearing carbonyl functionality. The reaction may proceed through the insertion of carbon monoxide (CO) into the Pd-alkyl intermediate followed by trapping with an alcohol nucleophile.
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