You can introduce the carbamoylethynyl moiety by reacting your starting material with an appropriate amine to form an amide bond. The amine should have the carbamoylethynyl group, for example, a propargyl amine. You can use peptide coupling reagents or other suitable methods for amide bond formation.
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3-(adamantan-1-ylcarbamoylethynyl)-1-benzenesulfonyl-4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester
Propanamide, N-methyl-N-(4-methylphenyl)-
C33H26NO3PS
Piperidine, 4-ethenyl-1-methyl- (9CI)
C12H19NO3
