Facile amide formation via S -nitrosothioacids

DOI: 10.1021/ol1031393

Source and publish data:

Organic Letters p. 1092 - 1094 (2011)

Update date:2022-08-03

Topics: Amide Formation Facile Experimental

Authors:

Pan, Jia

Devarie-Baez, Nelmi O.

Xian, Ming

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Article abstract of DOI:10.1021/ol1031393

Here we report a novel amide bond formation strategy from simple thioacid and amine starting materials. The reaction is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis.(Figure Presented)

Full text of DOI:10.1021/ol1031393

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