A bifunctional catalyst is a catalyst that contains two distinct functional groups that work together to facilitate the reaction. In enantioselective Strecker-type reactions, bifunctional catalysts often contain both a Lewis acid (to activate the carbonyl group of the substrate) and a Lewis base (to control the stereochemistry of the reaction).
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2-(9H-fluoren-9-ylamino)-2-phenylacetonitrile
(1S)-1-[(1R)-1-(4-chloro-phenyl)-2-nitro-ethyl]-2-oxo-cyclopentanecarboxylic acid methyl ester
(S)-(+)-6,7-bis(benzoyloxy)-1-cyano-1-methyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid ethyl ester
α-tert-Butoxyphenylacetonitril
