This involves understanding the impact of TLR2 antagonists on the immune system. To do this, researchers typically evaluate their effects on various immune cells, such as macrophages, dendritic cells, and B cells. The antagonist's ability to inhibit TLR2 signaling and the downstream production of inflammatory cytokines and chemokines is a critical aspect of biological characterization. It is important to assess the antagonist's selectivity for TLR2 compared to other TLRs.
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ethyl 3-[(3,4-dimethoxybenzoyl)amino]benzoate
4-(3-chloropyridin-2-yl)benzonitrile
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(3-iodo-4-methoxy-5-nitrophenyl)propanoate
1-[(2-benzyloxyethoxy)methyl]-3-aminocarbonylpyridinium chloride
