This involves understanding the impact of TLR2 antagonists on the immune system. To do this, researchers typically evaluate their effects on various immune cells, such as macrophages, dendritic cells, and B cells. The antagonist's ability to inhibit TLR2 signaling and the downstream production of inflammatory cytokines and chemokines is a critical aspect of biological characterization. It is important to assess the antagonist's selectivity for TLR2 compared to other TLRs.
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