Compactin, also known as mevastatin, is a natural compound that was initially isolated from Penicillium citrinum. It is a competitive inhibitor of the enzyme HMG-CoA reductase, which is a key enzyme in the biosynthesis of cholesterol. Compactin was one of the first statin drugs, a class of medications used to lower cholesterol levels. It played a significant role in the development of statin drugs that are widely used to treat high cholesterol and prevent cardiovascular diseases.
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