The γ-carboxyethyl thymine monomer should be properly protected to ensure selective coupling. Common protecting groups used in PNA synthesis include Fmoc (9-fluorenylmethoxycarbonyl) or Boc (tert-butyloxycarbonyl) groups. The protected γ-carboxyethyl thymine monomer is coupled to the solid support-bound PNA chain using appropriate coupling reagents (e.g., HBTU/HOBt or similar). The reaction typically occurs in a suitable solvent, such as DMF (dimethylformamide), under controlled conditions.
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5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester
