Demethylxanthohumol is often prenylated, meaning it has prenyl groups attached to it. These prenyl groups need to be removed before the cyclization step. This can be achieved by treating demethylxanthohumol with a suitable reagent or enzyme that cleaves the prenyl groups.
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(+/-)-3,4,8,9-Tetrahydro-5-hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-2H,10H-benzo<1,2-b:3,4-b'>dipyran-10-on
Benzenesulfonamide, N-(3-methyl-2-butenyl)-N-2-propenyl-
