The diketopiperazine (DKP) cyclization is a key step in dimeric pentapeptide synthesis. This cyclization involves the formation of a cyclic structure from the Glu-Asp dipeptide ester. You can promote this reaction by adjusting the pH and using suitable coupling reagents. The DKP formation involves the formation of a peptide bond between the N-terminus of the first amino acid and the C-terminus of the second amino acid, resulting in the cyclization.
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(2S,13S,16S,22S,25S)-5-amino-2-(4-aminobutyl)-10-{[(1S)-5-amino-1-carboxypentyl]carbamoyl}-13,22-bis(carboxymethyl)-4,12,15,19,21,24-hexaoxo-16,25-bis({[(2S)-5-oxopyrrolidin-2-yl]carbonyl}amino)-20-oxa-3,11,14,23-tetraazaoctacosane-1,28-dioic acid (non-pr
