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Directed evolution

The process of artificially guiding the evolution of enzymes to enhance their function for specific applications.

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Synthesis Elemental analysis Asymmetric synthesis Enantiomer Lipase Regioselectivity Diastereoselectivity Green chemistry Residue Oligomer Solid-phase synthesis Lewis acid Column chromatography Characterization Melting point Crystallization Yield NMR spectroscopy Distillation Catalyst Enantioselective Cleavage Thin-layer chromatography (TLC) Selectivity Ligand Nucleophile Electrophile Molecular docking Solvent Stereochemistry Lead compound Infrared (IR) spectroscopy Enantioselectivity Deprotonation Chromatography Recrystallization Optimization Boiling point Protonation Hydrolysis Mass spectrometry (MS) IC50 Differential scanning calorimetry (DSC) Atom economy Solubility Pharmacophore Potency Reagent Cyclization Scaffold