Bioorganic and Medicinal Chemistry Letters p. 1740 - 1743 (2006)
Update date:2022-08-03
Topics: Synthesis Elemental analysis Asymmetric synthesis Enantiomer Regioselectivity Diastereoselectivity Green chemistry Residue Oligomer Solid-phase synthesis Lewis acid Column chromatography Characterization Melting point Crystallization Yield NMR spectroscopy Distillation Catalyst Cleavage Thin-layer chromatography (TLC) Selectivity Ligand Nucleophile Electrophile Molecular docking Solvent Stereochemistry Lead compound Infrared (IR) spectroscopy Enantioselectivity Deprotonation Chromatography Recrystallization Optimization Boiling point Protonation Mass spectrometry (MS) IC50 Differential scanning calorimetry (DSC) Atom economy Solubility Pharmacophore Potency Reagent Cyclization Scaffold Polymer Conformation binding affinity
Antuch, Walfrido
Menon, Sanjay
Chen, Quin-Zene
Lu, Yingchun
Sakamuri, Sukumar
Beck, Barbara
Schauer-Vukasinovic, Vesna
Agarwal, Seema
Hess, Sibylle
Doemling, Alexander
A terphenyl α-helix mimetic scaffold recognized to be capable of disrupting protein-protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthes
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Doi:10.1016/0040-4039(84)80039-8
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