If the ring substituents are electron-withdrawing, they generally deactivate the ring towards nucleophilic attack. The presence of such groups can make the reaction slower as compared to a reaction with a more electron-rich substrate. Nitro groups (-NO2) are common electron-withdrawing substituents. They decrease the electron density on the ring, making it less nucleophilic and hence less reactive.
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3-NITRO-2-(1-PYRROLIDINYL)PYRIDINE
1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol
