Phorboxazole A contains a large macrocyclic ring. Forming this macrocycle is one of the critical challenges in the synthesis. Strategies for macrocycle formation include ring-closing metathesis (RCM), which is often employed to construct this large ring.
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4-((E)-2-{(2R,3S,4S,5S,6R)-6-[2-(4-Methoxy-benzyloxy)-ethyl]-3,5-dimethyl-4-triethylsilanyloxy-tetrahydro-pyran-2-yl}-propenyl)-2-methyl-oxazole
