Late-Stage Functionalization

Asymmetric synthesis Characterization Optimization Building blocks Protecting groups Purification Retrosynthetic analysis Purification and characterization Functional group manipulation Final steps Workup and Purification Scale-up Stereochemistry Control Stereochemical Control Literature Review Biological Evaluation Selection of Starting Materials Photoredox Catalysis Construction of the Core Structure SelectfluorTM Hypervalent Iodine Reagents Electrochemical Fluorination Organocatalytic Fluorination Amidation Construction of Fragments Analytical Techniques Final steps and purification Intermolecular Chiral Building Blocks Strategic Bond Formations Complex Cyclizations Introduction of Side Chains Key Reactions Iridium-Catalyzed Formation of the B-Ring Elaboration of B-Ring Formation of the C-Ring Elaboration of C-Ring Testing and Analysis sp3 C-H Bonds Formation of Macrocyclic Ring Synthetic Strategy unactivated methyl group