This classic method involves the reaction of pyrrole with an acyl chloride (RCOCl) in the presence of a Lewis acid catalyst like aluminum chloride (AlCl3). The reaction proceeds through electrophilic aromatic substitution and usually acylates the pyrrole at the 2-position. To achieve regioselectivity, you can modify the reaction conditions, such as the choice of Lewis acid and reaction temperature.
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7H-Indol-7-one, 1,4,5,6-tetrahydro-
(1E,4E)-1-(dimethylamino)-5-(4-methoxyphenyl) penta-1,4-dien-3-one
2-(hydroxy-phenyl-methyl)-naphthalene-1-carboxylic acid diethylamide
benzene
Ether
sulfuric acid
1-(4-hydroxy-2-methylphenyl)butane-1-one
(2-chloro-6-fluorophenyl)(4-methoxyphenyl)methanone
