HCV

Hepatitis C virus, a blood-borne virus that infects the liver and can cause chronic liver disease.

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Imidazo[1,2-a]pyridines that directly interact with hepatitis C NS4B: Initial preclinical characterization
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Synthesis and evaluation of novel potent HCV NS5A inhibitors
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Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876
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Synthesis Evaluation Spectrophotometry Inhibitors Imidazo[1,2-a]pyridines Pharmacophore Potency High-performance liquid chromatography (HPLC) Novel Structure-Activity Relationship (SAR) Studies Formulation and Delivery Lead Optimization Mechanism of Action Toxicity and Safety Biochemical Assays Pharmacokinetics and Pharmacodynamics Cell-Based Assays Discovery Compound Screening Potent Development Experimental Cell-based assay Toxicity testing Non-nucleoside inhibitor Structural class

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