Through a series of iterations, researchers may modify the chemical structure of the hybrid compounds to improve their potency and selectivity. SAR studies help in refining the design and enhancing the therapeutic potential of these molecules.
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
4-(3-AMINOPROP-1-YL)AMINOQUINOLINE
(4-Amino-3-iodophenyl)acetic acid
1-methoxy-5-nitro-4-phenylisoquinoline
2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
3-Pyridinol,4-methoxy-(9CI)
3-tert-butyl-5-[(3,4-dihydro-2H-thiochromen-8-yloxy)methyl]-1,3-oxazolidin-2-one
3-(4-chlorophenyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carbaldehyde
(2R,3R)-3-Allyl-azetidine-1,2-dicarboxylic acid 1-benzyl ester
3-(2-chloro-4-hydroxyphenylethynyl)-2-methylcyclohex-2-enone
dibenzyl N-(phosphonoacetyl)aspartate
1-Methyl-5-(5-nitro-2-propoxyphenyl)-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
3-(3,4-dimethoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one
5'-deoxy-5'-(4-nitrobenzamido)thymidine
ethyl-5-(2,4-dibenzyloxy-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylate
2-phenyl-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one
5-N-carbobenzoxylamino-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosidonic acid methyl ester
2-(5H-purin-6-yloxy)ethanol
Benzamide, N-(2-hydroxy-3-phenoxypropyl)-4-nitro-
(2S)-cyclohexyl({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid
Benzenesulfonamide, 4-[2-[[(2-propenylamino)thioxomethyl]amino]ethyl]-
Boc-Pro-Lys(Z)-Pro-OCH3
)
2-aza-4'-demethyldeoxypodophyllotoxin
N,N'-bis(3-aminophenyl)urea
N-[2-(dimethylamino)ethyl]phenazine-1-carboxamide
3-(4-methoxy-phenyl)-1-(4-prop-2-ynyloxy-phenyl)-propenone
2-[4-(4-Ethoxy-phenyl)-butyl]-isoindole-1,3-dione
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(3-phenylpropyl)-2,4-pentadienamide
trans-cinnamic pivalic anhydride
Boc-Ala-Aba-OH
6-(2,3-dihydroxy-benzoylamino)-hexanoic acid benzyl ester
4-[(2-methoxyethoxy)methyl]benzoic acid
C21H21BrN2O2
Ethanone, 2-(6-amino-9H-purin-9-yl)-1-phenyl-
2-(4-methoxybenzylidene)cyclohexane-1,3-dione
(Z)-5-(4-benzyloxyphenyl)methylidene-2-thioxo-4-thiazolidinone
betulin 3β-O-2,3,4-tri-O-benzoyl-α-L-arabinopyranoside
((3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate
2,2'-di-[[(3-methyl-4-methoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole
2-((benzoyloxy)methyl)-5-(4,5-diamino-2-oxopyrimidin-1(2H)yl)tetrahydrofuran-3,4-diyl dibenzoate
1-Pyrrolidinecarboxylic acid, 2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-, 1,1-dimethylethyl ester, (2S)-
2-BENZYLIDENEHYDRAZINE-1-CARBOTHIOAMIDE
THIOSEMICARBAZIDE
2-((4-chlorophenyl)disulfanyl)pyridine
Thiophenol
Iodine
N,N'-(1,4-phenylene)bis(2-fluorobenzenesulfonamide)
Pyridine
