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Chemical Baike

Isomerism

Isomerism, which involves the arrangement of atoms within the retinoid molecule, can influence its interaction with retinoid receptors. For example, all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis-RA) have distinct isomeric structures. RXRs have high affinity for 9-cis-RA, while RARs primarily bind to ATRA.

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