The choice of ligand is essential in this reaction to control the regioselectivity of the carboxylation. Different ligands can guide the nickel catalyst to produce specific regioisomers of carboxylic acids.
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Heptanoic acid,2-ethenyl-
(+/-)-1-phenylbutane-1,3-diol
1,2-bis(bis(2-cyclohexylphenyl)phosphino)ethane
