The macrolactone ring is typically formed through a cyclization reaction, often involving the reaction of a carboxylic acid with an alcohol or amine group, or through a similar strategy. This step creates the large cyclic structure that is characteristic of macrolactone natural products.
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2-Acetyl-3,5-dihydroxyphenylacetic acid ethyl ester
tert-butyl(2-(2R,5R)-5-{[(tert-butyldimethylsilyloxy)methyl]tetrahydrofuran-2-yl}-ethoxy)diphenylsilane
