The Negishi coupling is a cross-coupling reaction, typically involving the reaction of two different ynamide molecules. The reaction is named after its developer, Professor Ei-ichi Negishi. It usually involves the use of a transition metal catalyst, often palladium, and an organozinc reagent to facilitate the cross-coupling of ynamides. This reaction allows for the formation of more complex molecules by connecting different fragments.
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2-(2-(triisopropylsilyl)ethynyl)-N-(2-(naphthalen-1-yl)ethynyl)-N-tosylbenzenamine
4,4-Dimethyl-5-oxo-2-phenethyl-tetrahydro-furan-3-carboxylic acid ethyl ester
