Control the regioselectivity of the enolate addition to the β-lactam ring. This can be achieved by using specific conditions and appropriate protecting groups on the substrate.
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(3S,4R)-4-Butyl-1-(tert-butyl-diphenyl-silanyl)-3-((R)-1-hydroxy-ethyl)-azetidin-2-one
4,4-difluoro-4-(phenylthio)methyl-1,3-dioxolan-2-one
