Steroid backbone

The core four-ring structure of ethisterone used for functionalization.

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Click chemistry inspired highly facile synthesis of triazolyl ethisterone glycoconjugates
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Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities
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Synthesis Regioselectivity Hydroxyl group Yield NMR spectroscopy Bioassay Stereochemistry Chromatography Mass spectrometry (MS) TLC (thin-layer chromatography) HPLC (high-performance liquid chromatography) Protecting group Workup Structure-Activity Relationship (SAR) Click Chemistry Glycoconjugate Functional group Azide-alkyne cycloaddition Antagonist activity Molar ratio Solvent system Estrogen Receptor (ER)

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