Estrogen Receptor (ER)

A nuclear hormone receptor that binds estrogen and regulates gene expression.

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Synthesis and estrogen receptor affinity of 2,3-diarylindoles
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Selenium labeling in nuclear medicine. 2. D ring substituted estrogens
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- 17α-<(phenylseleno)ethynyl>-17β-estradiol
Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities
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- 3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol
2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor
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- 2',3'-di-O-benzoyl-5'-O-(4-methoxytrityl)-2'-C-methyluridine

Synthesis Antagonist Regioselectivity Hydroxyl group Yield NMR spectroscopy Selectivity Bioassay Ligand Stereochemistry Affinity Chromatography Mass spectrometry (MS) IC50 binding affinity Protecting group Chelation Docking Studies Structure-Activity Relationship (SAR) High-Throughput Screening (HTS) Thermodynamic Stability Radiolabeling Biodistribution Gel Electrophoresis Substituent Cell-based assay Agonist Antagonist activity 2,3-diarylindoles Radiochemical purity Luciferase assay Radioligand Binding Assay Western blot Half-life (t?) Transfection EC50 Off-target effects Steroid backbone

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