The hydroxamate group is a crucial component of collagenase inhibitors. This group can be introduced by reacting the appropriately protected amine with a sulfonyl chloride or sulfonyl anhydride, and then subsequently converting the resulting sulfonyl amide to a hydroxamate using a base like hydroxylamine.
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(S)-2-[Methanesulfonyl-(2-nitro-benzyl)-amino]-propionic acid
