The amine or amine derivative, the coupling partner, and the activated copper catalyst are combined in a suitable solvent. The amine's nucleophilic nitrogen atom can react with the electrophilic component (e.g., an alkyne or aryl halide) in a copper-catalyzed coupling reaction. This forms an intermediate with the aminomethyl group attached to a carbon atom.
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2-ethynyl-4-(methoxycarbonyl)-N-(p-toluenesulfonyl)aniline
1-(1-cyclohexyl-3-(4-methoxyphenyl)prop-2-ynyl)piperidine
o-deuterioiodobenzene
4-(t-butyl)phenylsulfoxy chloride
