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Trapidil

  • Name Trapidil
  • EINECS239-434-2
  • CAS No. 15421-84-8
  • Density1.21 g/cm3
  • PSA46.32000
  • LogP1.27890
  • SolubilityN/A
  • Melting Point98-99.4° (Pfeifer); 102-104° from heptane (Tenor)
  • FormulaC10H15N5
  • Boiling PointN/A
  • Molecular Weight205.263
  • Flash PointN/A
  • Transport InformationN/A
  • AppearanceN/A
  • Safety26
  • Risk Codes36/37/38
  • Molecular Structure
    Molecular Structure of 15421-84-8 (7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE)
  • Hazard SymbolsXi
  • SynonymsXi
  • Article Data5

Trapidil Specification

1. Introduction of Trapidil

Trapidil, with the IUPAC Name of N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, is one kind of white or almost white crystalline powder. Trapidil has been used for anti-angina drug.

2. Properties of Trapidil

(1)Density: 1.2 g/cm3; (2)Index of Refraction: 1.625; (3)XLogP3-AA: 1.7; (4)H-Bond Donor: 0; (5)H-Bond Acceptor: 4.

3. Structure Descriptors of Trapidil

You could convert the following datas into the molecular structure:
(1).Canonical SMILES: CCN(CC)C1=CC(=NC2=NC=NN12)C
(2).InChI: InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3 
(3).InChIKey: GSNOZLZNQMLSKJ-UHFFFAOYSA-N

4. Toxicity of Trapidil

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 155mg/kg (155mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 
mouse LD50 intravenous 101mg/kg (101mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
mouse LD50 oral 380mg/kg (380mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 
mouse LD50 subcutaneous 132mg/kg (132mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 
rat LD50 intraperitoneal 100mg/kg (100mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 
rat LD50 intravenous 76mg/kg (76mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 
rat LD50 oral 235mg/kg (235mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 
rat LD50 subcutaneous 100mg/kg (100mg/kg)   Pharmazie. Vol. 26, Pg. 554, 1971.
 

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