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Tris(2-chloroethyl)amine

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Name

Tris(2-chloroethyl)amine

EINECS N/A
CAS No. 555-77-1 Density 1.21g/cm3
PSA 3.24000 LogP 2.00480
Solubility N/A Melting Point -4°
Formula C6H12 Cl3 N Boiling Point 156.2°Cat760mmHg
Molecular Weight 204.527 Flash Point 48.3°C
Transport Information N/A Appearance N/A
Safety Experimental poison by ingestion, inhalation, skin contact, subcutaneous, and intravenous routes. Moderately toxic to humans by inhalation. Questionable carcinogen with experimental carcinogenic data. An eye irritant. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl and NOx. See also AMINES. Risk Codes N/A
Molecular Structure Molecular Structure of 555-77-1 (TRIS-(2-CHLOROETHYL)-AMINE) Hazard Symbols N/A
Synonyms

Triethylamine,2,2',2''-trichloro- (8CI); 2,2',2''-Trichlorotriethylamine; HN 3; HN 3(cytostatic); Lekamin; NSC 260424; Nitrogen mustard (HN 3); SK 100; TS 160;Tri-2-chloroethylamine; Trichlormethine; Tris(2-chloroethyl)amine; Tris(b-chloroethyl)amine

Article Data 24

Tris(2-chloroethyl)amine Chemical Properties

IUPAC Name: 2-Chloro-N,N-bis(2-chloroethyl)ethanamine
CAS: 555-77-1
Following is the Molecular Structure of Tris(2-chloroethyl)amine (555-77-1):

SMILES: ClCCN(CCCl)CCCl
InChI: InChI=1/C6H12Cl3N/c7-1-4-10(5-2-8)6-3-9/h1-6H2
InChIKey: FDAYLTPAFBGXAB-UHFFFAOYAC
Std.InChI: InChI=1S/C6H12Cl3N/c7-1-4-10(5-2-8)6-3-9/h1-6H2
Std.InChIKey: FDAYLTPAFBGXAB-UHFFFAOYSA-N
Molecular Formula: C6H12Cl3N
Molecular Weight: 204.53
Boiling Point: 156.2℃ at 760mmHg
Flash Point: 48.3℃
Molar Volume: 168.9cm3
Density: 1.21g/cm3
Index of Refraction: 1.481
Molar Refractivity: 48.11cm3
Surface Tension: 35.2dyne/cm
Polarizability: 19.07 10-24cm3
Enthalpy of Vaporization: 39.29kJ/mol
Vapour Pressure: 2.92mmHg at 25℃

Tris(2-chloroethyl)amine Uses

 Tris(2-chloroethyl)amine (555-77-1) can be used as a delayed-action casualty military agent.

Tris(2-chloroethyl)amine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 31600ug/kg (31.6mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LC50 inhalation 80mg/m3/10M (80mg/m3)   National Technical Information Service. Vol. PB158-508,
dog LC50 inhalation 100mg/m3/10M (100mg/m3)   National Technical Information Service. Vol. PB158-508,
dog LD50 skin 1mg/kg (1mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947.
dog LD50 subcutaneous 20mg/kg (20mg/kg)   National Technical Information Service. Vol. PB158-507,
dog LDLo intravenous 1mg/kg (1mg/kg)   National Technical Information Service. Vol. PB158-507,
domestic animals - goat/sheep LD50 skin 20mg/kg (20mg/kg)   National Technical Information Service. Vol. PB158-507,
guinea pig LC50 inhalation > 200mg/m3/10M (200mg/m3)   National Technical Information Service. Vol. PB158-508,
guinea pig LD50 skin 20mg/kg (20mg/kg)   National Technical Information Service. Vol. PB158-507,
guinea pig LD50 subcutaneous 7mg/kg (7mg/kg)   National Technical Information Service. Vol. PB158-507,
mouse LC50 inhalation 120mg/m3/10M (120mg/m3)   National Technical Information Service. Vol. PB158-508,
mouse LD50 intravenous 19500ug/kg (19.5mg/kg)   Cesko-Slovenska Farmacie. Vol. 15, Pg. 455, 1966.
mouse LD50 skin 7mg/kg (7mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947.
mouse LD50 subcutaneous 6900ug/kg (6.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD National Technical Information Service. Vol. PB158-507,
quail LD50 oral 133mg/kg (133mg/kg)   Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
rabbit LC50 inhalation 140mg/m3/10M (140mg/m3)   National Technical Information Service. Vol. PB158-508,
rabbit LD50 skin 5mg/kg (5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD National Technical Information Service. Vol. PB158-507,
rabbit LD50 subcutaneous 2mg/kg (2mg/kg)   National Technical Information Service. Vol. PB158-507,
rat LC50 inhalation 200mg/m3/10M (200mg/m3)   National Technical Information Service. Vol. PB158-508,
rat LD50 oral 5mg/kg (5mg/kg)   National Technical Information Service. Vol. PB158-507,
rat LD50 skin 2mg/kg (2mg/kg)   National Technical Information Service. Vol. PB158-507,
rat LD50 subcutaneous 2mg/kg (2mg/kg)   National Technical Information Service. Vol. PB158-507,
rat LD50 unreported 2500ug/kg (2.5mg/kg)   Pharmaceutical Bulletin. Vol. 1, Pg. 297, 1953.

Tris(2-chloroethyl)amine Consensus Reports

EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Tris(2-chloroethyl)amine Safety Profile

RIDADR: 2810
HazardClass: 6.1(a)
PackingGroup: I
Experimental poison by ingestion, inhalation, skin contact, subcutaneous, and intravenous routes. Moderately toxic to humans by inhalation. Questionable carcinogen with experimental carcinogenic data. An eye irritant. Human mutation data reported.

Tris(2-chloroethyl)amine Specification

 Tris(2-chloroethyl)amine (555-77-1) also can be called for 2,2',2''-Trichlorotriethylamine ; 2,2',2-Trichlorotriethylamine ; 2,2',2"-Trichloro-triethylamin ; 2,2',2"-Trichlorotriethylamine ; 2,2',2''-Trichloro-triethylamin ; 2,2',2''-Trichlorotriethylamine ; 2-Chloro-n,n-bis(2-chloroethyl)-ethanamin ; 2-Chloro-N,N-bis(2-chloroethyl)ethanamine . Tris(2-chloroethyl)amine (555-77-1) is a liquid with faint odor of fish and soap,no odor when it is pure.When Tris(2-chloroethyl)amine (555-77-1) dissolved in water, it is a strong base; reacts violently with strong oxidants and acids;attacks Copper and Copper compounds.When heated to decomposition it emits very toxic fumes of Cl− and NOx .Be attention of this chemical is highly toxic.

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