Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Tropicamide

Related Products

Hot Products

Name

Tropicamide

EINECS 216-140-2
CAS No. 1508-75-4 Density 1.161 g/cm3
PSA 53.43000 LogP 2.20620
Solubility 0.2g/L(25 oC) Melting Point 98 °C
Formula C17H20N2O2 Boiling Point 492.8 °C at 760 mmHg
Molecular Weight 284.358 Flash Point 251.8 °C
Transport Information N/A Appearance crystalline solid
Safety 22-26-36-36/37/39 Risk Codes 20/21/22-36/37/38-42/43-41-37/38-22
Molecular Structure Molecular Structure of 1508-75-4 (Tropicamide) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

Visumidriatic;Tropic acid-N-ethyl-N-(g-picolyl)amide;Mydriat;Mydril;Mydrin M;Mydriaticum;N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide;Epitromina;Mydrapid;

Article Data 9

Tropicamide Synthetic route

N-ethyl-N-(4-pyridylmethyl)-α-methylethyl-phenylacetamide

1508-75-4

tropicamide

Conditions
ConditionsYield
With hydrogenchloride In water at 55℃;95%
529-64-6

Tropic acid

C8H12N2*ClH

1508-75-4

tropicamide

Conditions
ConditionsYield
With triethylamine In water; toluene Reflux;90.4%
529-64-6

Tropic acid

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

1508-75-4

tropicamide

Conditions
ConditionsYield
Stage #1: Tropic acid With triethylamine; acetyl chloride In toluene at 50℃; for 3h;
Stage #2: With thionyl chloride In toluene for 5h;
Stage #3: 4-(ETHYLAMINOMETHYL)PYRIDINE With α-[(acetyloxy)methyl]benzeneacetic acid; triethylamine In toluene at 0 - 10℃;
75.9%
14510-37-3

3-acetoxy-2-phenyl-propionyl chloride

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

1508-75-4

tropicamide

Conditions
ConditionsYield
With pyridine; chloroform Erwaermen des Reaktionsprodukts mit wss. HCl;
33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

(+-)-tropoyl chloride

(+-)-tropoyl chloride

1508-75-4

tropicamide

Conditions
ConditionsYield
With chloroform; triethylamine
83-13-6

diethyl 2-phenylmalonate

1508-75-4

tropicamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: inorganic base solvent / 0.5 h / 0 °C / pH 9
2: thionyl chloride / dichloromethane / 12 h / 10 °C
3: tetrahydrofuran / 10 h / 10 °C
4: potassium borohydride / 12 h / 30 °C / pH 8
View Scheme

Tropicamide Specification

The Tropicamide, with the CAS registry number 1508-75-4, is also known as (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide. It belongs to the product categories of Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Heterocyclic Compounds; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Acetylcholine Receptor. Its EINECS registry number is 216-140-2. This chemical's molecular formula is C17H20N2O2 and molecular weight is 284.3529. Its IUPAC name is called N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide. This chemical's classification codes are Anticholinergic [ophthalmic]; Autonomic Agents; Cholinergic Agents; Cholinergic Antagonists; Drug / Therapeutic Agent; Muscarinic antagonists; Mydriatics; Neurotransmitter Agents; Peripheral Nervous System Agents. Tropicamide (Mydriacyl) is an anticholinergic used as a mydriatic. Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. It's reported that tropicamide is used as intravenous street drug in Russia.

Physical properties of Tropicamide: (1)ACD/LogP: 1.16; (2)ACD/LogD (pH 5.5): 1.01; (3)ACD/LogD (pH 7.4): 1.15; (4)ACD/BCF (pH 5.5): 3.22; (5)ACD/BCF (pH 7.4): 4.42; (6)ACD/KOC (pH 5.5): 73.32; (7)ACD/KOC (pH 7.4): 100.7; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 7; (11)Index of Refraction: 1.586; (12)Molar Refractivity: 82.2 cm3; (13)Molar Volume: 244.8 cm3; (14)Surface Tension: 51.3 dyne/cm; (15)Density: 1.161 g/cm3; (16)Flash Point: 251.8 °C; (17)Enthalpy of Vaporization: 80.02 kJ/mol; (18)Boiling Point: 492.8 °C at 760 mmHg; (19)Vapour Pressure: 1.58E-10 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
(2)InChI: InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
(3)InChIKey: BGDKAVGWHJFAGW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 695mg/kg (695mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
mouse LD50 oral 565mg/kg (565mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
mouse LD50 subcutaneous 665mg/kg (665mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
rat LD50 intraperitoneal 1210mg/kg (1210mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
rat LD50 oral 865mg/kg (865mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
rat LD50 subcutaneous 872mg/kg (872mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1508-75-4