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| CAS No.: | 9002-07-7 |
|---|---|
| Name: | Trypsin |
| Molecular Structure: | |
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| Formula: | Unspecified |
| Molecular Weight: | 372.1 |
| Synonyms: | Cocoonase;Pancreatic Trypsin Novo;Parenzyme;Parenzymol;Pseudotrypsin;Sperm receptor hydrolase;Tripcellim;Tryptar;Tryptec Formula One;Trypure;Trypzean;Typtar; |
| EINECS: | 232-650-8 |
| Density: | 1.37[at 20℃] |
| Melting Point: | 115°C |
| Solubility: | Soluble in water (10 mg/ml), phosphate buffers (10 mg/ml), and balanced salt solutions (1 mg/ml). |
| Appearance: | white or whitish powder |
| Hazard Symbols: | R36/37/38:; R42:; |
| Risk Codes: | Xn,B |
| Safety: | 22-24-26-36/37-45-23 |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Consensus Reports
Reported in EPA TSCA Inventory.
Specification
The IUPAC name of this chemical is Trypsin. The CAS registry number is 9002-07-7 and the EINECS registry number is 232-650-8. It is converted into its active form by enteropeptidase in the small intestine. And it is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. It belongs to the class of Hydrolases; Specialty Enzymes; Diagnostic reagents; ProteasesAnalytical Enzymes; Trypsin for General Research ApplicationsCell Culture; USP Chemicals and Reagents Enzyme Class Index; Cell DissociationApplication Index; Reagents and Supplements; Enzymes, Inhibitors, and Substrates; ProteasesEnzyme Class Index.
Preparation of Trypsin: it is produced in the pancreas in the form of the inactive zymogen trypsinogen. When the pancreas is stimulated by cholecystokinin, it is then secreted into the first part of the small intestine the duodenum via the pancreatic duct.
Uses of Trypsin: it has been used widely in various biotechnological processes. It can be used to re-suspend cells adherent to the cell culture dish wall during the process of harvesting cells. It can also be used to dissociate dissected cells. In addition, it can be used to break down casein in breast milk. Moreover, it is used to dissolve blood clots in its microbial form and treat inflammation in its pancreatic form. Besides, it is used in baby food to pre-digest it.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. And it may cause sensitization by inhalation and skin contact. During using it, wear suitable protective clothing and gloves and do not breathe dust and vapour. You should avoid contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intravenous | 30000units/kg (30000units/kg) | BEHAVIORAL: GENERAL ANESTHETIC BLOOD: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956. |
| mouse | LD50 | intramuscular | 105mg/kg (105mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. | |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Farmakologiya i Toksikologiya Vol. 45(6), Pg. 78, 1982. | |
| mouse | LD50 | intravenous | 11100ug/kg (11.1mg/kg) | Drugs in Japan Vol. 6, Pg. 523, 1982. | |
| mouse | LD50 | oral | 1450mg/kg (1450mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. | |
| rabbit | LD50 | intravenous | 2200ug/kg (2.2mg/kg) | Drugs in Japan Vol. 6, Pg. 523, 1982. | |
| rat | LD50 | intramuscular | 200mg/kg (200mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. | |
| rat | LD50 | intraperitoneal | > 51mg/kg (51mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. | |
| rat | LD50 | intravenous | 36mg/kg (36mg/kg) | Farmakologiya i Toksikologiya Vol. 45(6), Pg. 78, 1982. | |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. |