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Name	Tween 80	EINECS	500-019-9
CAS No.	9005-65-6	Density	1.064
PSA	133.14000	LogP	4.46260
Solubility	Soluble	Melting Point		-21oC
Formula	C24H44O6	Boiling Point	> 100 C
Molecular Weight	428.600006103516	Flash Point	>110 ºC
Transport Information	200kgs	Appearance	pale yellow oily liquid
Safety	Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.	Risk Codes	22-36/37/38-37/38-41
Molecular Structure		Hazard Symbols	UN NO.
Synonyms	Sorbitan,mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-;Sorbitan,monooleate, polyoxyethylene derivs. (8CI);Glycols, polyethylene, ether withsorbitan monooleate (8CI);Alkamuls PSMO 20;Alkamuls T 80;Atlox 1087;Atlox8916TF;Canarcel TW 80;Capmul POE-O;Cemerol T 80;Cemesol TW 1020;Crill 10;Crill 11;Crill S 10;Crillet 4;Crillet 4 HP;Crillet 4 Super;Crillet 41;Crodalan AWS;Disponil SMO 120;Disponil SMO 120 Spez;Durfax 80;E 433;E 433(polyglycol);Ecoteric 20;Ecoteric T 80;Emalex ET 8020;Emasol O 105R;Emsorb6900;Emulson 10OM;Ethoxylated sorbitan monooleate;Ethsorbox O 20;Ethylan GE08;Ethylene oxide-sorbitan monooleate polymer;Eumulgin SMO 20;Flo Mo SMO 20;Glycosperse O 20;Glycosperse O 5;Hexaethylene glycol sorbitan monooleate;Hodag SVO 9;Ionet T 80;Ionet T 80C;Ionet T 80V;Ionet-T 80PA;Lamesorb SMO20;Liposorb O 20VBE;MO 55F;Montanox 80;Montanox 81VG;Montanox DF 80;Myvatex MSPS;Nikkol TO 10;Nikkol TO 106;Nikkol TO 10M;Nikkol TO 10MV;Nikkol TO 10V;Nissan Nonion OT 220;Nissan Nonion OT 221;Nofable ESO 9920;Nonio-light 0-30;Nonio-light SPO 1;Nonion OT 220;Nonion OT 221;Olothorb;PEG sorbitan monooleate;PEO(20) sorbitan monooleate;POE sorbitan monooleate;Polisorbac 60;Polyethoxylated sorbitan monooleate;Polyethylene glycolsorbitan ether monooleate;Polyethylene glycol sorbitan monooleate;Polyoxyethylated sorbitan monooleate;Polyoxyethylene monosorbitan monooleate;Polyoxyethylene sorbitan monooleate;Polyoxyethylenesorbitan oleate;Polysorban80;Polysorbate 80;Polysorbate 81;Radiasurf 7157;Rheodol Super TW-O 120;Rheodol TQ-O 106;Rheodol TW 0120V;Rheodol TW-O 106;Rheodol TW-O 106V;Rheodol TW-O 120;Rheodol TW-O 120V;Romulgin O;SVO 9;Setrolene O;Silvan T80;Simugel EG;Sorbax PMO 20;Sorbimacrogol oleate;Sorbimacrogol oleate 100;Sorbimacrogol oleate 300;Sorbital O 20;Sorbitan monooleate ethylene oxideadduct;Sorbitan monooleate polyethylene glycol ether;Sorbitan monooleatepolyoxyethylene ether;Tween 80;

Tween 80 Consensus Reports

Reported in NTP Carcinogenesis Studies (feed); Equivocal Evidence: rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-415 ,1992. ; (feed); No Evidence: mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-415 ,1992. . Reported in EPA TSCA Inventory.

Tween 80 Specification

The Tween 80,with the CAS registry number 61791-14-8, is also known as Polyoxyethylene sorbitan monooleate;Sorbimacrogol oleate 300; Sorbital 0 20. It belongs to the product categories of Organics;Catalyst and assistant;assistant. What's more,Its systematic name is Polyoxyethylene sorbitan monooleate. The Tween 80 is Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives,complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Uses of Tween 80:
(1).Polysorbate 80 is often used in ice cream to prevent milk proteins from completely coating the fat droplets.
(2).Polysorbate 80 is also used as an emulsifier in the manufacture of medications for parenteral administration, most notably in the popular anti-arrhythmic amiodarone.

Safety and Storage of the Tween 80:
The Tween 80 is moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.When you contact it avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes,avoid ingestion and inhalation.As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.And it Store in a cool, dry place. Store in a tightly closed container. Store at around 20°C.

The toxicity data of Tween 80 as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	500mg/kg (500mg/kg)	CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978.
dog	LDLo	intravenous	500mg/kg (500mg/kg)	CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978.
mammal (species unspecified)	LD50	intravenous	5800mg/kg (5800mg/kg)		Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991.
mammal (species unspecified)	LD50	oral	25gm/kg (25000mg/kg)		Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991.
mouse	LD50	intraperitoneal	7600mg/kg (7600mg/kg)		Pharmacology and Therapeutics. Vol. 5, Pg. 467, 1979.
mouse	LD50	intravenous	4500mg/kg (4500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 666, 1968.
mouse	LD50	oral	25gm/kg (25000mg/kg)		Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962.
rat	LD50	intraperitoneal	6804mg/kg (6804mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 804, 1985.
rat	LD50	intravenous	1790mg/kg (1790mg/kg)		FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974.
rat	LD50	oral	34500uL/kg (34.5mL/kg)		Food Research. Vol. 21, Pg. 348, 1956.

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