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VINDESINE
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  • Name VINDESINE
  • EINECS258-682-2
  • CAS No. 53643-48-4
  • Density1.41g/cm3
  • PSA164.82000
  • LogP3.37350
  • SolubilityN/A
  • Melting Point230-232oC
  • FormulaC43H55 N5 O7
  • Boiling Point°Cat760mmHg
  • Molecular Weight753.939
  • Flash Point°C
  • Transport InformationN/A
  • AppearanceN/A
  • SafetyMutation data reported. When heated to decomposition it emits toxic vapors of NOx.
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 53643-48-4 (DESACETYLVINBLASTINEAMIDE)
  • Hazard SymbolsN/A
  • SynonymsN/A

VINDESINE Chemical Properties

IUPAC Name: 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
The MF of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4) is C43H55N5O7.

                        
The MW of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4) is 753.93.
Synonyms of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4): Compound 112531 ; Eldisine ; Fildesin ; VDS ; Vindesine
Apperance: ethanol - methanol crystallization
Melting Point: 230～232 °C
Index of Refraction: 1.708  
EINECS: 258-682-2
Density: 1.41 g/ml

VINDESINE Uses

   3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4) is used as anti-cancer drug.Its mechanism inhibit the proliferation of cells, spindle formation, so that cell growth stopped in mid-mitosis for cell cycle-specific drugs. For lung cancer, malignant lymphoma, breast cancer, esophageal cancer, childhood acute lymphoblastic leukemia, chronic myelogenous leukemia, melanoma, germ cell tumors, ovarian cancer and so on.

VINDESINE Production

With vinblastine as raw materials, under normal pressure, and the reaction of anhydrous hydrazine and then restore the received vindesine.

VINDESINE Toxicity Data With Reference

1.    

mnt-ipr-ham 1100 µg/kg

     MUREAV    Mutation Research. 174 (1986),11.
2.    

ipr-mus LD50:4 mg/kg

     BAXXDU    British UK Patent Application. (U.S. Patent Office, Science Library, 2021 Jefferson Davis Highway, Arlington, VA 22202) #2086884 .
3.    

ivn-mus LD50:13800 µg/kg

     JMCMAR    Journal of Medicinal Chemistry. 28 (1985),1079.

VINDESINE Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
Safety information of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4):
RIDADR  1544
HazardClass  6.1(a)
PackingGroup  II

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