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| CAS No.: | 100-92-5 |
|---|---|
| Name: | Mephentermine |
| Molecular Structure: | |
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|
|
| Formula: | C11H17 N |
| Molecular Weight: | 163.263 |
| Synonyms: | Phenethylamine,N,a,a-trimethyl- (8CI);2-(Methylamino)-2-methyl-1-phenylpropane; Mephentermine; Mephine; N,a,a-Trimethyl-b-phenethylamine; N,a,a-Trimethylphenethylamine; N-Methyl-w-phenyl-tert-butylamine; N-Methylphentermine; Vialin;Wyamine |
| EINECS: | 202-901-6 |
| Density: | 0.903g/cm3 |
| Melting Point: | <25 °C |
| Boiling Point: | 229.4°Cat760mmHg |
| Flash Point: | 90°C |
| PSA: | 12.03000 |
| LogP: | 2.61800 |
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β-Hydroxymephentermin
- 100-92-5
mephentermine
| Conditions | Yield |
|---|---|
| With thionyl chloride anschliessend Hydrierung des jeweils erhaltenen Reaktionsprodukts an Palladium/BaCO3 in Methanol; | |
| With hydrogenchloride anschliessend Hydrierung des jeweils erhaltenen Reaktionsprodukts an Palladium/BaCO3 in Methanol; |
- 61765-66-0
N-(2-methyl-1-phenylpropan-2-yl)-1-phenylmethanimine
- 74-88-4
methyl iodide
- 100-92-5
mephentermine
| Conditions | Yield |
|---|---|
| anschliessend mit wss. Aethanol; |
| Conditions | Yield |
|---|---|
| at 90℃; for 2184h; Product distribution; other temperatures, other times, also in acidic solutions; stability under various conditions; |
| Conditions | Yield |
|---|---|
| (i) H2SO4, AcOH, (ii) /BRN= 1855608/, (iii) LiAlH4, Et2O; Multistep reaction; |
- 100-92-5
mephentermine
| Conditions | Yield |
|---|---|
| With hydrogen; sodium acetate; nickel In methanol |
| Conditions | Yield |
|---|---|
| With diethyl ether |
- 34405-42-0
α-(1-amino-1-methylethyl)benzenemethanol
- 100-92-5
mephentermine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: aqueous hydriodic acid; phosphorus 3: anschliessend mit wss. Aethanol View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 2: anschliessend mit wss. Aethanol View Scheme |
| Conditions | Yield |
|---|---|
| With acetic acid; platinum Hydrogenation; |
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Chemistry
Molecule structure of Mephentermine (CAS NO.100-92-5):
.gif)
IUPAC Name: N,2-Ddimethyl-1-phenylpropan-2-amine
Molecular Weight: 163.25938 [g/mol]
Molecular Formula: C11H17N
Index of Refraction: 1.501
Molar Refractivity: 53.26 cm3
Molar Volume: 180.6 cm3
Polarizability: 21.11×10-24 cm3
Surface Tension: 31 dyne/cm
Density: 0.903 g/cm3
Flash Point: 90 °C
Enthalpy of Vaporization: 46.6 kJ/mol
Boiling Point: 229.4 °C at 760 mmHg
Vapour Pressure: 0.0697 mmHg at 25 °C
XLogP3: 2.4
H-Bond Donor: 1
H-Bond Acceptor: 1
Rotatable Bond Count: 3
Exact Mass: 163.1361
MonoIsotopic Mass: 163.1361
Topological Polar Surface Area: 12
Heavy Atom Count: 12
Complexity: 123
Canonical SMILES: CC(C)(CC1=CC=CC=C1)NC
InChI: InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3
InChIKey: RXQCGGRTAILOIN-UHFFFAOYSA-N
EINECS: 202-901-6
Classification Code of Mephentermine (CAS NO.100-92-5): Adrenergic Agonists; Adrenergic agents; Adrenergic alpha-agonists; Autonomic Agents; Cardiovascular Agents; Drug / Therapeutic Agent; Neurotransmitter Agents; Peripheral Nervous System Agents; Sympathomimetics; Vasoconstrictor agents
Uses
Mephentermine (CAS NO.100-92-5) was formerly used in Wyamine nasal decongestant inhalers and before that as a stimulant in psychiatry. It is also used as a treatment for hypotension.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 89mg/kg (89mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT | Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972. |
| mouse | LD50 | intravenous | 43mg/kg (43mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: EXCITEMENT BEHAVIORAL: TREMOR | Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972. |
| mouse | LD50 | oral | 57mg/kg (57mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT | Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972. |
| rat | LD50 | intraperitoneal | 85mg/kg (85mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT | Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972. |
| rat | LD50 | intravenous | 13mg/kg (13mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT | Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 111, Pg. 169, 1972. |
Specification
Mephentermine (CAS NO.100-92-5) is also named as Mephentermine ; Mephentermine [INN:BAN] ; 2-Methyl-2-methylamino-1-phenylpropane ; 2-Methylamino-2-methyl-1-phenylpropane ; Benzeneethanamine, N,alpha,alpha-trimethyl- ; Mefenterdrin ; Mefentermin ; Mefentermina ; Mefentermina [INN-Spanish] ; Mephenterdrine ; Mephenterdrinum ; Mephentermine ; Mephenterminum ; Mephenterminum [INN-Latin] ; Mephetedrine ; Mephine ; N,alpha,alpha-Trimethylbenzeneethanamine ; N,alpha,alpha-Trimethylphenethylamine ; N-Methyl-omega-phenyl-t-butylamine ; N-Methyl-omega-phenyl-tert-butylamine ; N-Methylphentermine Phenethylamine, N,alpha,alpha-trimethyl- ; Wyamine ; Wyfentermina ; omega-Phenyl-tert-butyl-methylamine ; Benzeneethanamine, N,alpha,alpha-trimethyl- ; Mephentermine ; Phenethylamine, N,alpha,alpha-trimethyl- . It is a cardiac stimulant.