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| CAS No.: | 1038924-70-7 |
|---|---|
| Name: | 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- |
| Article Data: | 16 |
| Molecular Structure: | |
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| Formula: | C18H19NO |
| Molecular Weight: | 265.355 |
| Synonyms: | 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-;(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one;(3R,5S)-;Sacubitril Impurity 18;LCZ699;(3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one |
| Density: | 1.083±0.06 g/cm3(Predicted) |
| Boiling Point: | 474.0±24.0 °C(Predicted) |
| PSA: | 29.10000 |
| LogP: | 3.74950 |
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- 149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With sodium hydroxide In tetrahydrofuran; methanol | 95% |
| With lithium hydroxide In ethanol Reflux; |
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal In methanol at 20℃; for 5h; | 95% |
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol at 50℃; under 7600.51 Torr; for 6h; Temperature; | 92.3% |
| With sulfuric acid; palladium 10% on activated carbon; hydrogen at 40℃; for 30h; | 80.6% |
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 18h; | 92% |
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol at 80℃; under 30003 Torr; for 24h; | 89% |
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol at 20℃; Reagent/catalyst; Solvent; | 88% |
- 92-66-0
4-bromo-1,1'-biphenyl
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| Stage #1: (3R,5S)-5-(iodomethyl)-3-methyl-2-pyrrolidinone With chloro-trimethyl-silane; ethylene dibromide; zinc In N,N-dimethyl acetamide at 0 - 5℃; for 1h; Inert atmosphere; Stage #2: 4-bromo-1,1'-biphenyl With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide at 5℃; for 24h; Negishi Coupling; | 87.8% |
- 3315-91-1
4-biphenylylmagnesium bromide
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With copper(l) cyanide In tetrahydrofuran at -30 - 20℃; Inert atmosphere; | 82.3% |
- 92-66-0
4-bromo-1,1'-biphenyl
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| Stage #1: 4-bromo-1,1'-biphenyl With iodine; magnesium In tetrahydrofuran at 0 - 60℃; Inert atmosphere; Stage #2: (3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone With iron(III)-acetylacetonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 82% |
- 1447173-69-4
C7H13NO4S
- 5122-94-1
4-biphenylboronic acid
- 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In water; dimethyl sulfoxide at 80℃; for 10h; Reagent/catalyst; Solvent; Inert atmosphere; | 82% |
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