CAS No.112022-83-0,(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Suppliers

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Basic Information

Molecular Structure:
CAS No.:	112022-83-0
Name:	(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
Article Data:	8

Formula:	C₁₈H₂₀BNO
Molecular Weight:	277.174
Synonyms:	(3aR)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole;1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole,tetrahydro-1-methyl-3,3-diphenyl-, (R)-;(R)-Me-CBS;(R)-Me-Corey-Bakshi-Shibatareagent;(R)-Methyl-CBS;(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole;(R-Methyl-Corey-Bakshi-Shibata catalyst;
EINECS:	-0
Density:	1.12 g/cm³
Melting Point:	85-95 ºC
Boiling Point:	377.5 ºC at 760 mmHg
Flash Point:	182.1ºC
Solubility:	Not miscible or difficult to mix in water.
Appearance:	white to light yellow crystal powder
Hazard Symbols:	F,Xn,Xi
Risk Codes:	11-38-48/20-63-65-67-36/37-19
Safety:	36/37-62-33-29-16-2
Transport Information:	UN 1294 3/PG 2
PSA:	12.47000
LogP:	3.48070

Synthetic route

: 22348-32-9, 63401-04-7, 112022-88-5, 112068-01-6
(S)-diphenylprolinol

: 13061-96-6
dihydroxy-methyl-borane

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

Conditions

Conditions	Yield
In hexane at 30℃; Solvent; Temperature; Inert atmosphere; Reflux;	81%

: 823-96-1
Trimethylboroxine

: 22348-32-9
(R)-α,α-diphenylprolinol

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

Conditions

Conditions	Yield
In toluene Heating;
With borane In toluene at 20 - 150℃; for 4.5h;
In toluene at 20℃; for 0.5h;

: 13061-96-6
dihydroxy-methyl-borane

: 22348-32-9
(R)-α,α-diphenylprolinol

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

Conditions

Conditions	Yield
With 4 A molecular sieve In toluene at 20℃; for 1h;	80 mg
In toluene Reflux; Dean-Stark;

: 7318-81-2
bis(methoxy)methylborane

: 22348-32-9
(R)-α,α-diphenylprolinol

A: 67-56-1
methanol

B: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

Conditions

Conditions	Yield
In toluene at 20℃; for 1h; Product distribution / selectivity;

...Expand

: 5447-74-5
methyl 3-(4-methoxybenzoyl)propionate

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: 848044-56-4
(S)-methyl 4-hydroxy-4-(4’-methoxyphenyl)butyrate

Conditions

Conditions	Yield
With boron trifluoride-tetrahydrofuran complex In toluene at -78℃;	96%

: C51H60O7Si

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: C51H62O7Si

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran; toluene at -40℃; for 2h;	95%

: methyl 2,4-bis(methoxymethoxy)-6-(3-((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)-2-oxopropyl) benzoate

: 13292-87-0
dimethyl sulfide borane

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: methyl 2,4-dihydroxy-6-(3-((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)-2-oxopropyl) benzoate

Conditions

Conditions	Yield
Stage #1: dimethyl sulfide borane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran at 0℃; for 0.5h; Stage #2: methyl 2,4-bis(methoxymethoxy)-6-(3-((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)-2-oxopropyl) benzoate In tetrahydrofuran at -20℃; for 12h; Reagent/catalyst;	90%

...Expand

: 100331-89-3
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

Conditions

Conditions	Yield
In tetrahydrofuran; hydrogenchloride; ethyl acetate liquid HCl;	76%

: 357405-87-9
3-chloro-1-(3-isoxazolyl)-1-propanone

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: 357405-40-4
(S)-α-(2-Chloroethyl)-5-isoxazolemethanol

Conditions

Conditions	Yield
With borane In tetrahydrofuran; methanol; toluene	13%

: 77-78-1
dimethyl sulfate

: 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: 144119-12-0
(R)-(+)-1-methyl-α,α-diphenyl-2-pyrrolidinemethanol

Conditions

Conditions	Yield
With potassium carbonate In water

Raw Materials

823-96-1

Downstream Products

Total:144 Page 1 of 4 1 2 3 4 Next>>

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Chemistry

MF: C₁₈H₂₀BNO
MW: 277.17
Appearance: white to light yellow crystal powde
mp: 85-95 °C(lit.)
bp: 111 °C
density: 0.95 g/mL at 25 °C
refractive index: 68 ° (C=1, MeOH)
Fp: 40 °F
storage temp.: 2-8°C
Sensitive: Air & Moisture Sensitive

Safety Profile

Hazard Codes: F,Xn,Xi
Risk Statements: 11-38-48/20-63-65-67-36/37-19
Safety Statements: 36/37-62-33-29-16-2
RIDADR: UN 1294 3/PG 2
F: 10
HazardClass: 3
PackingGroup: II