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| CAS No.: | 112022-83-0 |
|---|---|
| Name: | (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole |
| Molecular Structure: | |
|
|
|
| Formula: | C18H20BNO |
| Molecular Weight: | 277.174 |
| Synonyms: | (3aR)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole;1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole,tetrahydro-1-methyl-3,3-diphenyl-, (R)-;(R)-Me-CBS;(R)-Me-Corey-Bakshi-Shibatareagent;(R)-Methyl-CBS;(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole;(R-Methyl-Corey-Bakshi-Shibata catalyst; |
| EINECS: | -0 |
| Density: | 1.12 g/cm3 |
| Melting Point: | 85-95 ºC |
| Boiling Point: | 377.5 ºC at 760 mmHg |
| Flash Point: | 182.1ºC |
| Solubility: | Not miscible or difficult to mix in water. |
| Appearance: | white to light yellow crystal powder |
| Hazard Symbols: |
 F, Xn, Xi
|
| Risk Codes: | 11-38-48/20-63-65-67-36/37-19 |
| Safety: | 36/37-62-33-29-16-2 |
| Transport Information: | UN 1294 3/PG 2 |
| PSA: | 12.47000 |
| LogP: | 3.48070 |
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- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
- 22348-32-9, 63401-04-7, 112022-88-5, 112068-01-6
(S)-diphenylprolinol
- 13061-96-6
dihydroxy-methyl-borane
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
| Conditions | Yield |
|---|---|
| In hexane at 30℃; Solvent; Temperature; Inert atmosphere; Reflux; | 81% |
- 823-96-1
Trimethylboroxine
- 22348-32-9
(R)-α,α-diphenylprolinol
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
| Conditions | Yield |
|---|---|
| In toluene Heating; | |
| With borane In toluene at 20 - 150℃; for 4.5h; | |
| In toluene at 20℃; for 0.5h; |
- 13061-96-6
dihydroxy-methyl-borane
- 22348-32-9
(R)-α,α-diphenylprolinol
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
| Conditions | Yield |
|---|---|
| With 4 A molecular sieve In toluene at 20℃; for 1h; | 80 mg |
| In toluene Reflux; Dean-Stark; |
- 7318-81-2
bis(methoxy)methylborane
- 22348-32-9
(R)-α,α-diphenylprolinol
A
- 67-56-1
methanol
B
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
| Conditions | Yield |
|---|---|
| In toluene at 20℃; for 1h; Product distribution / selectivity; |
- 5447-74-5
methyl 3-(4-methoxybenzoyl)propionate
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
- 848044-56-4
(S)-methyl 4-hydroxy-4-(4’-methoxyphenyl)butyrate
| Conditions | Yield |
|---|---|
| With boron trifluoride-tetrahydrofuran complex In toluene at -78℃; | 96% |
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
| Conditions | Yield |
|---|---|
| With borane-THF In tetrahydrofuran; toluene at -40℃; for 2h; | 95% |
- 13292-87-0
dimethyl sulfide borane
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
| Conditions | Yield |
|---|---|
| Stage #1: dimethyl sulfide borane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran at 0℃; for 0.5h; Stage #2: methyl 2,4-bis(methoxymethoxy)-6-(3-((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)-2-oxopropyl) benzoate In tetrahydrofuran at -20℃; for 12h; Reagent/catalyst; | 90% |
- 100331-89-3
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
- 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one
| Conditions | Yield |
|---|---|
| In tetrahydrofuran; hydrogenchloride; ethyl acetate liquid HCl; | 76% |
- 357405-87-9
3-chloro-1-(3-isoxazolyl)-1-propanone
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
- 357405-40-4
(S)-α-(2-Chloroethyl)-5-isoxazolemethanol
| Conditions | Yield |
|---|---|
| With borane In tetrahydrofuran; methanol; toluene | 13% |
- 77-78-1
dimethyl sulfate
- 112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
- 144119-12-0
(R)-(+)-1-methyl-α,α-diphenyl-2-pyrrolidinemethanol
| Conditions | Yield |
|---|---|
| With potassium carbonate In water |
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Chemistry
MW: 277.17
Appearance: white to light yellow crystal powde
mp: 85-95 °C(lit.)
bp: 111 °C
density: 0.95 g/mL at 25 °C
refractive index: 68 ° (C=1, MeOH)
Fp: 40 °F
storage temp.: 2-8°C
Sensitive: Air & Moisture Sensitive
Safety Profile
Risk Statements: 11-38-48/20-63-65-67-36/37-19
Safety Statements: 36/37-62-33-29-16-2
RIDADR: UN 1294 3/PG 2
F: 10
HazardClass: 3
PackingGroup: II