Products Categories
| CAS No.: | 112245-13-3 |
|---|---|
| Name: | (S)-TERT-LEUCINOL |
| Article Data: | 58 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H15NO |
| Molecular Weight: | 117.191 |
| Synonyms: | 1-Butanol,2-amino-3,3-dimethyl-, (S)-;(2S)-2-Amino-3,3-dimethyl-1-butanol;(S)-(+)-2-Amino-3,3-dimethylbutanol;(S)-(+)-tert-Leucinol;(S)-2-Amino-3,3-dimethyl-1-butanol;(S)-2-Amino-3,3-dimethylbutanol;L-tert-Leucinol; |
| Density: | 0.907 g/cm3 |
| Melting Point: | 30-34 °C(lit.) |
| Boiling Point: | 198.5 °C at 760 mmHg |
| Flash Point: | 73.8 °C |
| Appearance: | white crystalline low melting mass |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 46.25000 |
| LogP: | 1.05240 |
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
- 20859-02-3
L-tert-Leucine
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; iodine In tetrahydrofuran for 24h; Heating; | 100% |
| Stage #1: L-tert-Leucine With iodine In tetrahydrofuran for 24h; Reflux; Stage #2: With methanol Stage #3: With potassium hydroxide In water | 100% |
| With sodium tetrahydroborate; iodine In tetrahydrofuran at 0 - 80℃; for 22h; Inert atmosphere; | 100% |
- 297746-06-6
[2-[(4S)-4-(tert-butyl-1,3-oxazolin-2-yl)]phenyl]diphenylphosphino-1-one
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 6h; Hydrolysis; Heating; | 85% |
- 157985-17-6
(-)-(3R,5S)-5-(1,1-dimethylethyl)-3-phenylmorpholin-2-one
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In methanol under 112509 Torr; for 72h; | 82% |
| With hydrogen; palladium on activated charcoal In methanol under 114000 Torr; for 72h; Hydrogenolysis; ring cleavage; methanolysis; | 82% |
- 63038-27-7
L-tert-leucine methyl ester hydrochloride
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In ethanol; water for 5.5h; Heating; |
- 43165-46-4
sodium 3,3-dimethyl-2-oxobutyrate
A
- 112245-13-3
(S)-tert-leucinol
B
- 3907-02-6, 93684-72-1, 112245-13-3, 112245-09-7
(2R)-2-amino-3,3-dimethylbutan-1-ol
| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate; sulfuric acid In 1,2-dimethoxyethane for 48h; Ambient temperature; resolution with (S)-mandelic acid; Yield given. Yields of byproduct given; | |
| With sodium tetrahydroborate; sulfuric acid In 1,2-dimethoxyethane for 48h; Ambient temperature; resolution with N-(2-naphthoyl)-(S)-tert-leucine; Yield given. Yields of byproduct given; |
- 207398-94-5
(S)-3,3-Dimethyl-2-((S)-1-phenyl-ethylamino)-butan-1-ol
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| With hydrogen S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415.; |
- 5469-26-1
1-Bromopinacolon
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 90 percent / dimethylformamide / 15 h / 20 °C 2: hydrobromic acid; acetic acid 3: potassium carbonate 4: hydrogen / platinum oxide hydrate / methanol / 20 °C / 760 Torr 5: 82 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr View Scheme |
- 157985-06-3
5-(1,1-dimethylethyl)-3R-phenyl-3,6-dihydro-[1,4]oxazin-2-one
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: hydrogen / platinum oxide hydrate / methanol / 20 °C / 760 Torr 2: 82 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr View Scheme | |
| Multi-step reaction with 2 steps 1: 89 percent / H2 / PtO2 / methanol / 5 h / 760 Torr 2: 82 percent / H2 / 10percent Pd/C / methanol / 72 h / 112509 Torr View Scheme |
- 261963-27-3
(-)-(R)-(phenyl)(phenylmethoxycarbonylamino)acetic acid 3,3-dimethyl-2-oxo-butyl ester
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: hydrobromic acid; acetic acid 2: potassium carbonate 3: hydrogen / platinum oxide hydrate / methanol / 20 °C / 760 Torr 4: 82 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr View Scheme | |
| Multi-step reaction with 3 steps 1: aq. HBr / acetic acid 2: 89 percent / H2 / PtO2 / methanol / 5 h / 760 Torr 3: 82 percent / H2 / 10percent Pd/C / methanol / 72 h / 112509 Torr View Scheme |
- 112245-13-3
(S)-tert-leucinol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: potassium carbonate 2: hydrogen / platinum oxide hydrate / methanol / 20 °C / 760 Torr 3: 82 percent / hydrogen / Pd/C / methanol / 72 h / 114000 Torr View Scheme |
What can I do for you?
Get Best Price
Chemistry
Molecular Structure of 1-Butanol,2-amino-3,3-dimethyl-, (2S)- (CAS NO.112245-13-3):
.png)
IUPAC Name: [(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]azanium
Empirical Formula: C6H15NO
Molecular Weight: 117.189
H bond acceptors: 2
H bond donors: 3
Freely Rotating Bonds: 4
Polar Surface Area: 12.47 Å2
Index of Refraction: 1.451
Molar Refractivity: 34.84 cm3
Molar Volume: 129.1 cm3
Surface Tension: 32.7 dyne/cm
Density: 0.907 g/cm3
Flash Point: 73.8 °C
Enthalpy of Vaporization: 50.58 kJ/mol
Boiling Point: 198.5 °C at 760 mmHg
Vapour Pressure: 0.0906 mmHg at 25°C
Melting point: 30-34 °C(lit.)
Product Categories: Pharmaceutical Intermediates; Amino Alcohols; Amino Alcohols (Chiral); Chiral Building Blocks; Synthetic Organic Chemistry; Amino alcohols
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10-23
Specification
1-Butanol,2-amino-3,3-dimethyl-, (2S)- , with CAS number of 112245-13-3, can be called 2-Amino-3,3-dimethyl-1-butanol ; h-tle-ol;h-(tbu)gly-ol ; l-t-leucinol ; l-(+)-tert-leucinol ; l-tert-leucinol ; l-t-butylglycinol ; (s)-2-amino-3,3-dimethylbutanol ; (S)-2-Amino-3,3-dimethylbutanol ; (S)-2-Amino-3,3-dimethyl-1-butanol ; 1-Butanol,2-amino-3,3-dimethyl-, (S)- . It is a white crystalline low melting mass.