Products Categories
Basic Information
| CAS No.: | 113-73-5 |
|---|---|
| Name: | GRAMICIDIN C |
| Article Data: | 28 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C60H92 N12 O10 |
| Molecular Weight: | 1141.46 |
| Synonyms: | 1H,5H-Dipyrrolo[1,2-a:1',2'-p][1,4,7,10,13,16,19,22,25,28]decaazacyclotriacontine,cyclic peptide deriv.; Cyclo(L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl);Cyclo(L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl);Gramicidin C; Gramicidin C (Russian); Gramicidin S 1; Gramicidin S-A; Grammidin |
| Density: | 1.24g/cm3 |
| Boiling Point: | 1394.8°Cat760mmHg |
| Flash Point: | 797.4°C |
| Solubility: | 0.14g/L(28 oC) |
| PSA: | 353.38000 |
| LogP: | 4.71140 |
Related products
- 1137-41-3Methanone,(4-aminophenyl)phenyl-
- 1137-42-44-Hydroxybenzophenone
- 113756-89-1Boc-L-2-amino-5-phenylpentanoic acid dicyclohexylamine salt
- 113759-96-94-Piperidinone,1-(4-chlorophenyl)-
- 1137-67-31H-Benzimidazole,2-(3-pyridinyl)-
- 113770-21-12H-1,4-Benzoxazine,7-chloro-3,4-dihydro-
- 113770-87-9Pyridine,3-fluoro-4-(trifluoromethyl)-
- 113770-88-04-Pyridinecarbonitrile,3-fluoro-
- 113772-13-7Benzeneacetic acid, a-cyano-2-nitro-, methyl ester
- 113772-16-03-Thiophenecarboxaldehyde,2,5-dihydro-
Synthetic route
- 15207-29-1
Cyclo[(Val-Orn-(Cbz)-Leu-DPhe-Pro)2]
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen; palladium In acetic acid for 4h; | 90% |
| With hydrogen; palladium on activated charcoal Hydrogenolysis; | |
| With hydrogen |
- 83830-88-0
D-Phe-Pro-Val-Orn-Leu-D-Phe-Pro-Val-Orn-Leu
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| at 150℃; for 4h; Inert atmosphere; Neat (no solvent); | 87% |
- 41839-95-6
[Orn(Boc)2,2']gramicidin
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane for 0.5h; | 78% |
| With trifluoroacetic acid In dichloromethane for 1h; | |
| With chlorotriisopropylsilane; trifluoroacetic acid In water for 1.5h; | |
| With trifluoroacetic acid In water at 20℃; for 1h; | 57 mg |
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| With pyridine In N,N-dimethyl-formamide at 25℃; for 24h; | 65% |
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: C70H110N12O15 With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide Stage #2: With trifluoroacetic acid | 53% |
A
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: (S)-2-[(S)-5-tert-Butoxycarbonylamino-2-((S)-2-{[(S)-1-((R)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester With trifluoroacetic acid dealkoxycarbonylation; Stage #2: With pyridine In N,N-dimethyl-formamide at 25℃; for 24h; Dimerization; cyclization; | A 38% B 15% |
- 917501-50-9
Boc-D-Phe-Pro-Val-Orn(Boc)-OH
A
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: Boc-D-Phe-Pro-Val-Orn(Boc)-OH; H-Leu-oxime resin With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol Stage #2: With trifluoroacetic acid In dichloromethane for 0.5h; Stage #3: With acetic acid; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 25℃; for 24h; | A 35% B n/a |
...Expand
Conditions
| Conditions | Yield |
|---|---|
| With pyridine In N,N-dimethyl-formamide at 25℃; for 24h; Yield given. Yields of byproduct given; |
- 51926-52-4
D-Phe-L-Pro
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| Yield given. Multistep reaction; |
- 113-73-5
Gramicidin S
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: TentaGel-PEG-CONH-CH2CH2S-Leu-Orn-Val-Pro-D-Phe-Leu-Orn-Val-Pro-D-Phe-NH2 With 3-(N-morpholino)propanesulfonate buffer; GrsB TE at 37℃; for 3h; pH=7.0; Enzymatic reaction; Stage #2: With trifluoroacetic acid In water |
