CAS No.114915-17-2,7-Troc-paclitaxel Suppliers

Products Categories

Pharmaceutical (57)
Organic Chemicals (8)
Others (3)
Plant Extract (2)

Basic Information

Molecular Structure:
CAS No.:	114915-17-2
Name:	7-Troc-paclitaxel
Article Data:	2

Formula:	C₅₀H₅₂Cl₃NO₁₆
Molecular Weight:	1029.32
Synonyms:	7-Troc-Paclitaxel;Paclitaxel Impurity 50;(N-1)Paxlitaxl intermediate 2;7-(2,2,2-Trichloroethyloxycarbonyl)taxol;Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-...
Density:	1.46±0.1 g/cm3(Predicted)
Boiling Point:	1041.1±65.0 °C(Predicted)

Synthetic route

: 98-88-4
benzoyl chloride

: 114915-15-0
C43H48Cl3NO15

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; ethyl acetate	87%
In pyridine for 3h; Ambient temperature;

: 32981-86-5
10-deacetylbaccatin III

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 71 percent / pyridine / 0.5 h / 80 °C 2: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 3: 80 percent / HCOOH / 4 h / 20 °C 4: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

: 143615-00-3
(2R,3S)-3-amino-2-hydroxy-3-phenylpropionic acid ethyl ester

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 3: 100 percent / LiOH, H2O / ethanol / 20 °C 4: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 5: 80 percent / HCOOH / 4 h / 20 °C 6: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

: 144787-20-2
(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 2: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 4: 100 percent / LiOH, H2O / ethanol / 20 °C 5: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 6: 80 percent / HCOOH / 4 h / 20 °C 7: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

Yield

Multi-step reaction with 7 steps
1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
2: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
4: 100 percent / LiOH, H2O / ethanol / 20 °C
5: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C
6: 80 percent / HCOOH / 4 h / 20 °C
7: 87 percent / NaHCO3 / ethyl acetate; H2O
View Scheme

: 103150-33-0
7-(2,2,2-trichloroethyloxycarbonyl)baccatin III

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 80 percent / HCOOH / 4 h / 20 °C 3: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme
Multi-step reaction with 4 steps 1: 95 percent / dicyclohexylcarbodiimide, 4-dimethyl-aminopyridine, / 15 h / 70 °C 2: AgNO3, OsO4, / acetonitrile; 2-methyl-propan-2-ol / 24 h / Ambient temperature 3: ISi(CH3)3 / acetonitrile / 0.5 h / 0 °C 4: pyridine / 3 h / Ambient temperature View Scheme
Multi-step reaction with 4 steps 1: 95 percent / dicyclohexylcarbodiimide, 4-dimethyl-aminopyridine, / 15 h / 70 °C 2: AgNO3, OsO4, / acetonitrile; 2-methyl-propan-2-ol / 24 h / Ambient temperature 3: ISi(CH3)3 / acetonitrile / 0.5 h / 0 °C 4: pyridine / 3 h / Ambient temperature View Scheme

: 100-52-7
benzaldehyde

aminoguanidine salt: aminoguanidine salt

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1: 1.) Et3N, Bu2BOTf / 1.) CH2Cl2, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h 2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C 3: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 4: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 5: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 6: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 7: 100 percent / LiOH, H2O / ethanol / 20 °C 8: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 9: 80 percent / HCOOH / 4 h / 20 °C 10: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

Yield

Multi-step reaction with 10 steps
1: 1.) Et3N, Bu2BOTf / 1.) CH2Cl2, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h
2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C
3: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
4: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
5: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
6: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
7: 100 percent / LiOH, H2O / ethanol / 20 °C
8: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C
9: 80 percent / HCOOH / 4 h / 20 °C
10: 87 percent / NaHCO3 / ethyl acetate; H2O
View Scheme

: 115437-18-8
7-triethylsilyl-10-deacetylbaccatin III

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 67 percent / 0.1N HCl / ethanol / 24 h / 0 °C 2: 71 percent / pyridine / 0.5 h / 80 °C 3: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 4: 80 percent / HCOOH / 4 h / 20 °C 5: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

: 126060-73-9
ethyl (2R,3R)-3-phenyl-2,3-oxiranepropanoate

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 2: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 3: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 4: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 5: 100 percent / LiOH, H2O / ethanol / 20 °C 6: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 7: 80 percent / HCOOH / 4 h / 20 °C 8: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

Yield

Multi-step reaction with 8 steps
1: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
2: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
3: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
4: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
5: 100 percent / LiOH, H2O / ethanol / 20 °C
6: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C
7: 80 percent / HCOOH / 4 h / 20 °C
8: 87 percent / NaHCO3 / ethyl acetate; H2O
View Scheme

: 143527-75-7
(2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 2: 100 percent / LiOH, H2O / ethanol / 20 °C 3: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 4: 80 percent / HCOOH / 4 h / 20 °C 5: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme

: 143615-03-6, 143527-70-2
(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

: 114915-17-2
C50H52Cl3NO16

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 80 percent / HCOOH / 4 h / 20 °C 3: 87 percent / NaHCO3 / ethyl acetate; H2O View Scheme