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| CAS No.: | 119356-77-3 |
|---|---|
| Name: | Dapoxetine hydrochloride |
| Article Data: | 36 |
| Cas Database | |
| Molecular Structure: | |
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| Formula: | C21H23NO |
| Molecular Weight: | 305.42 |
| Synonyms: | Benzenemethanamine,N,N-dimethyl-a-[2-(1-naphthalenyloxy)ethyl]-,(S)-;(S)-(+)-Dapoxetine; |
| EINECS: | 1308068-626-2 |
| Density: | 1.081 g/cm3 |
| Boiling Point: | 454.4 °C at 760 mmHg |
| Flash Point: | 132.6 °C |
| Appearance: | White to off-white crystalline powder |
| PSA: | 12.47000 |
| LogP: | 4.91160 |
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History
Dapoxetine (CAS NO.119356-77-3) has been submitted for approval in the European Union and it is being reviewed. Dapoxetine received approval in Sweden, Finland, Austria, Portugal, Germany, Italy and Spain in 2009,. Approvals for dapoxetine are also anticipated in other European countries as well. Besides, filings for approval have been submitted in Canada, Australia, Mexico, Turkey and six other countries.
Specification
1. Introduction of Dapoxetinehydrochloride
Dapoxetinehydrochloride, with the IUPAC name of (1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine, is one kind of white or off-white powder. And this chemical belongs to the Product Categories of Erectile Dysfunction.
2. Properties of Dapoxetinehydrochloride
Dapoxetinehydrochloride has the following property datas: (1)Freely Rotating Bonds: 6; (2)Polar Surface Area: 12.47; (3)Index of Refraction: 1.607; (4)Molar Refractivity: 97.51 cm3; (5)Molar Volume: 282.2 cm3; (6)Surface Tension: 43.1 dyne/cm; (7)Density: 1.081 g/cm3; (8)Flash Point: 132.6 °C; (9)Enthalpy of Vaporization: 71.4 kJ/mol; (10)Boiling Point: 454.4 °C at 760 mmHg; (11)Vapour Pressure: 1.91E-08 mmHg at 25°C.
3. Structure Descriptors of Dapoxetinehydrochloride
You could convert the following datas into the molecular structure:
(1)SMILES: O(c2cccc1ccccc12)CC[C@@H](c3ccccc3)N(C)C
(2)InChI: InChI=1/C21H23NO/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21/h3-14,20H,15-16H2,1-2H3/t20-/m0/s1
(3)InChIKey: USRHYDPUVLEVMC-FQEVSTJZBM
(4)Std. InChI: InChI=1S/C21H23NO/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21/h3-14,20H,15-16H2,1-2H3/t20-/m0/s1
(5)Std. InChIKey: USRHYDPUVLEVMC-FQEVSTJZSA-N
4. Use of Dapoxetinehydrochloride
Dapoxetinehydrochloride is the only approved medication to treat premature ejaculation. Authors conclude that Dapoxetinehydrochloride is well-tolerated and improved measures associated with premature ejaculation, including reduction of personal distress, interpersonal difficulty and improvement in the satisfaction with the sexual intercourse.