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| CAS No.: | 1210344-57-2 |
|---|---|
| Name: | PF-04971729 |
| Article Data: | 15 |
| Molecular Structure: | |
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| Formula: | C22H25ClO7 |
| Molecular Weight: | 436.889 |
| Synonyms: | PF 04971729-00; 1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose; (1S,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol; cc-212 |
| Density: | 1.455 |
| Boiling Point: | 630.5±55.0 °C(Predicted) |
| PSA: | 108.61000 |
| LogP: | 1.35650 |
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- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With water; trifluoroacetic acid at 20℃; for 1h; | 92% |
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With hydrogenchloride; palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol; water at 30℃; for 8h; | 91.4% |
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With hydrogenchloride; palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol; water at 20℃; for 3h; | 89% |
| With palladium on activated charcoal; hydrogen In ethanol; ethyl acetate at 20℃; for 6h; | 80% |
| With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol; 1,2-dichloro-benzene at 25 - 30℃; under 1500.15 - 2625.26 Torr; for 6h; | 13.5 g |
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In water at 20℃; for 1h; | 85% |
- 1210763-25-9
{(2S,3S)-3,4,5-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6,8-dioxa-bicyclo[3.2.1]oct-1-yl}-methanol
A
- 1210344-57-2
Ertugliflozin
B
- 1210344-58-3
(1S,2S,3S,4S,5S)-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1-hydroxymethyl-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
| Conditions | Yield |
|---|---|
| With formic acid; palladium In tetrahydrofuran; ethanol at 20℃; for 2h; | A 29% B 15% |
- 1233482-00-2
C28H37ClO7S2
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid at 23℃; for 96h; stereoselective reaction; | 491 mg |
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: trifluoroacetic acid; triethylsilane / toluene / 20 °C 2: 5%-palladium/activated carbon; hydrogenchloride; hydrogen / toluene; methanol; water / 18 h / 25 °C / 2585.81 Torr / Inert atmosphere View Scheme |
- 1629222-50-9
(2S,3S,4R)-2,3,4-tris(benzyloxy)-1-((benzyloxy)-methyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With hydrogenchloride; 5%-palladium/activated carbon; hydrogen In methanol; water; toluene at 25℃; under 2585.81 Torr; for 18h; Inert atmosphere; | |
| With hydrogenchloride; 5%-palladium/activated carbon; hydrogen In methanol; water; toluene at 25℃; under 2585.81 Torr; for 18h; |
- 1298086-18-6
(1R,2S,3S,4R,5S)-1-(acetoxymethyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl triacetate
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol at 20℃; for 0.25h; | |
| With sodium methylate In methanol at 20℃; for 3.25h; Inert atmosphere; |
- 1431329-06-4
(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-(4-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4-methylpiperazin-1-yl)butan-1-one oxalate
- 1210344-57-2
Ertugliflozin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: sodium hydrogencarbonate / toluene; water / 0.17 h / 20 °C 2.1: n-butyllithium / toluene; 2-methyltetrahydrofuran; hexane / -15 - 20 °C / Inert atmosphere 2.2: 0.17 h / -15 °C / Inert atmosphere 3.1: trifluoroacetic acid; triethylsilane / toluene / 20 °C 4.1: 5%-palladium/activated carbon; hydrogenchloride; hydrogen / toluene; methanol; water / 18 h / 25 °C / 2585.81 Torr / Inert atmosphere View Scheme |
