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121629-14-9

Basic Information
CAS No.: 121629-14-9
Name: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester
Article Data: 3
Molecular Structure:
Molecular Structure of 121629-14-9 (Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester)
Formula: C8H12 F2 O2
Molecular Weight: 178.179
Synonyms: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester
Density: 1.13g/cm3
Boiling Point: 181.8oC at 760 mmHg
Flash Point: 62.4oC
PSA: 26.30000
LogP: 1.98490
Synthetic route
122665-97-8

4,4-difluorocyclohexanecarboxylic acid

67-56-1

methanol

121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 0 - 70℃; for 16h;90.82%
sulfuric acid for 16h; Reflux;
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

756-79-6

dimethyl methane phosphonate

1402838-40-7

dimethyl [2-(4,4-difluorocyclohexyl)-2-oxoethyl]phosphonate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: methyl 4,4-difluorocyclohexane-1-carboxylate In tetrahydrofuran at -78 - 0℃; for 1.5h; Inert atmosphere;
82%
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

178312-48-6

(4,4-difluorocyclohexyl)methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Inert atmosphere;81%
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: With potassium hydroxide In tetrahydrofuran; diethyl ether; water at 0℃; for 1h; Inert atmosphere;
81%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 18h; Inert atmosphere;77%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;71.55%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; ethanol at 0 - 20℃;
75-77-4

chloro-trimethyl-silane

121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

((4,4-difluorocyclohexylidene)(methoxy)methoxy)trimethylsilane

Conditions
ConditionsYield
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 2h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃; for 12h;
72%
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

74-88-4

methyl iodide

1360568-90-6

methyl 4,4-difluoro-1-methylcyclohexanecarboxylate

Conditions
ConditionsYield
Stage #1: methyl 4,4-difluorocyclohexane-1-carboxylate With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 2h;
Stage #2: methyl iodide In tetrahydrofuran at 20℃;
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1360569-34-1

(2S,3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-methylphenyl)6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 120 °C / Inert atmosphere
View Scheme
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1360569-47-6

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1360569-48-7

(2S,3R4R5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere
5.1: tert.-butyl lithium / tetrahydrofuran; toluene / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h / -78 °C
5.3: 12 h / 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 6 h / 0 °C / Inert atmosphere
7.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
8.1: ammonia / methanol / 20 °C
View Scheme
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1360568-91-7

(4,4-difluoro-1-methylcyclohexyl)methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
View Scheme
121629-14-9

methyl 4,4-difluorocyclohexane-1-carboxylate

1360568-92-8

(4,4-difluoro-1-methylcyclohexyl)methyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.1: triethylamine / dmap / 20 °C
View Scheme
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  • Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester  CAS:121629-14-9

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    Product Name: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester Synonyms: Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester;4,4-Difluorocyclohexanecarboxylic acid methyl ester;methyl 4,4-difluorocyclohexane-1-carboxylate CAS: 121

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    Methyl 4,4-difluorocyclohexanecarboxylate Alias: Benzene,(3,3-difluoropropyl); 1,1-difluoro-3-phenylpropane; 1,1-difluoro-4-carbomethoxy-cyclohexane; CAS RN:121629-14-9 Purity:98% Molecular formula: C8H12F2O2

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    Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

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  • 4,4-Difluorocyclohexanecarboxylic acid methyl es

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    SAGECHEM is a chemical R&D, manufacturing and distribution company since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-86818502

    Address:5Fl. 501Room, Tower A, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China

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  • Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

  • Casno:

    121629-14-9

    Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Zhejiang Jiuzhou Chemical Co.,Ltd is a market-oriented and innovation-driven biopharmaceutical company. The company is focusing on the R&D, manufacturing and sales of pharmaceutica

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    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 19334956669

    Address:Waisha Road,Jiaojiang

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  • Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

  • Casno:

    121629-14-9

    Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

    Min.Order: 10 Milligram

    FOB Price:  USD $ 0.0-0.0

    1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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  • Methyl 4,4-difluorocyclohexanecarboxylate

  • Casno:

    121629-14-9

    Methyl 4,4-difluorocyclohexanecarboxylate

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-9999.0

    Strong R&D strength and team We have a R&D team with around 30 R&D personnel.All of our employees have chemical backgrounds and have worked in the chemical industry for many years.Our laboratory can synthesize target products with wei

    Changzhou Pesan Chemical Co., Ltd. is a dynamic and specialized chemical company. Since our establishment, We provide raw materials and key intermediates for pharmaceutical industr

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86 021 61559630

    Address:No.7-9,Guanghua St.,Zhonglou District,Changzhou,China

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  • Methyl 4,4-difluorocyclohexanecarboxylate

  • Casno:

    121629-14-9

    Methyl 4,4-difluorocyclohexanecarboxylate

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0

    Comparing with other companies,we provide high purity product in a high value.If you want to try our product,we can send you some sample to test our product.We have the confidence to promise you the best quality. BTCpharm always uphold the custom

    BTC Pharmaceuticals Co. LTD is located in Building B8, Haimen Biotech and Pharmaceutical park, the total area is 4000 m2,the major business focus on process development, optimizati

  • BTC Pharmaceutical CO. LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0513-68015397

    Address:NO.100 lake dongting road linjiang town haimen

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  • methyl 4,4-difluorocyclohexane-1-carboxylate

  • Casno:

    121629-14-9

    methyl 4,4-difluorocyclohexane-1-carboxylate

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

    Wit Pharma is a high-tech pharmaceutical company integrating R&D, production and sales, which is committed to the research and development of small molecule pharmaceutical intermed

  • Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-18602559219

    Address:Nanjing

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  • Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

  • Casno:

    121629-14-9

    Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

    United Scientific Company (USC) Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. USC has both the expertise and flexibility

  • Shanghai united Scientific Co.,Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-53535353

    Address:28F No.900 huaihai Road Shanghai China

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  • Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

  • Casno:

    121629-14-9

    Cyclohexanecarboxylicacid, 4,4-difluoro-, methyl ester

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

    Chungking Joyinchem Co.,Ltd is a specialized Chinese chemical supplier focusing on product R&D, manufacture and marketing. Our head office locates in Wulong district and the facto

  • Chungking Joyinchem Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-23-77778019

    Address:No. 55, Longhu Road, Xiangkou Town, Wulong District, Chungking City, 408500, P.R China

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  • 121629-14-9 Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

  • Casno:

    121629-14-9

    121629-14-9 Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    121629-14-9 Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl esterAppearance:colorless clear liquid Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation

    Nanjing Raymon Biotech Co., Ltd. is specialized in developing and marketing middle & high level pharmaceutical intermediates. We are supplying different categories of high-quality

  • Nanjing Raymon Biotech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-025-52181296

    Address:Block B, No. 918, Shuanglong Avenue

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