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CAS No.: | 123-78-4 |
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Name: | D-ERYTHRO-SPHINGOSINE |
Article Data: | 120 |
Molecular Structure: | |
Formula: | C18H37NO2 |
Molecular Weight: | 299.497 |
Synonyms: | 4-Octadecene-1,3-diol,2-amino-, (E)-D-erythro- (8CI);4-Octadecene-1,3-diol, 2-amino-,[R-[R*,S*-(E)]]-;(-)-D-erythro-Sphingosine;(-)-Sphingosine;(2S,3R)-Sphingosine;(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol;(4E)-Sphingenine;4-Sphingenine;4-trans-Sphingenine;D-(+)-erythro-4-trans-Sphingenine;D-Sphingosine;D-erythro-C18-Sphingosine;D-erythro-Sphingosine;Erythrosphingosine;Sphingosine;erythro-4-Sphingenine;erythro-C18-Sphingosine;trans-4-Sphingenine; |
EINECS: | 204-651-3 |
Density: | 0.94 g/cm3 |
Melting Point: | 81-82 °C |
Boiling Point: | 445.922 °C at 760 mmHg |
Flash Point: | 223.486 °C |
Appearance: | White crystalline solid |
Safety: | 22-24/25 |
PSA: | 66.48000 |
LogP: | 4.62450 |
(2'E,4S,1'R)-4-(1'-hydroxyhexadec-2'-enyl)-1,3-oxazolidin-2-one
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With sodium hydroxide; ethanol at 80℃; for 2.5h; | 100% |
With sodium hydroxide In ethanol at 80℃; for 2.5h; | 100% |
With potassium hydroxide In ethanol for 2.5h; Heating; | 100% |
N-tert-butyloxycarbonylsphingosine
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
Stage #1: N-tert-butyloxycarbonylsphingosine With trifluoroacetic acid In dichloromethane at 50℃; for 2h; Stage #2: With sodium hydroxide; water In dichloromethane pH=~ 10; | 100% |
With hydrogenchloride; water In tetrahydrofuran at 20 - 50℃; for 18h; | 98% |
With trifluoroacetic acid for 0.5h; | 90% |
tert-butyl ((2S,3R,E)-1-((tert-butyldimethylsilyl)oxy)-3-hydroxy-octadec-4-en-2-yl)carbamate
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 1.5h; | 99% |
(4R,5S)-2,2-Di-tert-butyl-4-((E)-pentadec-1-enyl)-[1,3,2]dioxasilinan-5-ylamine
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride; acetic acid In tetrahydrofuran at 0℃; for 2h; | 98% |
N-[(2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl]-2,2,2-trifluoroacetamide
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
Stage #1: N-[(2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl]-2,2,2-trifluoroacetamide With sodium hydroxide In ethanol at 20℃; for 2h; Inert atmosphere; Stage #2: With water In ethanol | 96% |
With water; sodium hydroxide In ethanol at 20℃; for 2h; | 82.5% |
With potassium carbonate In ethanol at 50℃; for 5h; | 75% |
2-azido-sphingosine
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With hydrogen sulfide In pyridine; water for 48h; Ambient temperature; | 95% |
With pyridine; hydrogen sulfide In water for 48h; | 95% |
With sodium tetrahydroborate In isopropyl alcohol for 48h; Heating; | 92% |
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 45℃; for 3h; | 93% |
(2S,3R,4E)-2-amino-1-benzyloxyoctadec-4-en-3-ol
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With ammonia; sodium In diethyl ether at -78 - 20℃; for 5h; | 92% |
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 80℃; for 2h; | 92% |
Conditions | Yield |
---|---|
With ammonia; lithium In tetrahydrofuran for 2h; Heating; | 88% |
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IUPAC Name: (E,2S,3R)-2-aminooctadec-4-ene-1,3-diol
Molecular Formula: C18H37NO2
Molecular Weight: 299.49 g/mol
Canonical SMILES: C(=C\CCCCCCCCCCCCC)\[C@H]([C@H](CO)N)O
InChI: InChI=1/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
Mol File: 123-78-4.mol
EINECS: 204-651-3
Product Categories: Mixed Fatty Acids; Fatty Acid Derivatives & Lipids; Glycerols; Inhibitors; Protein Kinase Inhibitors and Activators; Protein Kinase
Solubility: chloroform: 20 mg/mL, clear, colorless to very faintly yellow
Merck: 13,8821
Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
Nominal Mass: 299
Average Mass: 299.4919
Monoisotopic Mass: 299.282429
H bond acceptors: 3
H bond donors: 4
Freely Rotating Bonds: 18
Polar Surface Area: 21.7
Index of Refraction: 1.489
Molar Refractivity: 92.02 cm3
Molar Volume: 318.7 cm3
Polarizability: 36.47×10-24cm3
Surface Tension: 38.2 dyne/cm
Density: 0.939 g/cm3
Flash Point: 223.5 °C
Enthalpy of Vaporization: 81.24 kJ/mol
Boiling Point: 445.9 °C at 760 mmHg
Melting Point: 81-82 °C
storage temperature: 20 °C
logP(octanol-water): 5.530
Atmospheric OH Rate Constant: 1.34E-10 cm3/molecule-sec at 25 °C
Vapour Pressure of Sphingosine (CAS NO.123-78-4): 7.96E-10 mmHg at 25 °C
1.Sphingosine (CAS NO.123-78-4) does not inhibit protein kinase A or myosin light chain kinase; it inhibits calmodulin-dependent enzymes; it is natural isomer of sphingosine .
2. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2. This leads to the formation of sphingosine-1-phosphate, a potent signaling lipid.
Safety Statements: 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK Germany of Sphingosine (CAS NO.123-78-4): 3
1. Sphingosine (CAS NO.123-78-4), its Synonyms are 2-Aminooctadec-4-ene-1,3-diol ; 4-Octadecene-1,3-diol, 2-amino-, (R-(R*,S*-(E)))- ; (E)-2-Amino-4-octadecan-1,3-diol . It is white crystalline solid.
2. Sphingosine is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.