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Basic Information
CAS No.: 131-49-7
Name: MEGLUMINE DIATRIZOATE
Molecular Structure:
Molecular Structure of 131-49-7 (MEGLUMINE DIATRIZOATE)
Formula: C11H9I3N2O4•C7H17NO5
Molecular Weight: 809.133
Synonyms: 3,5-diacetamido-2,4,6-triiodo-benzoicacicompd.with1-deoxy-1-(methylam;amidotrizoatemeglumine;angiografin;cardiografin;d-;d-glucitol,1-deoxy-1-(methylamino)-,3,5-bis(acetylamino)-2,4,6-triiodobenzo;diatrizoatemethylglucamine;gastrografin
Density: g/cm3
Melting Point: 189-193° (dec)
Boiling Point: 614.1°Cat760mmHg
Flash Point: 325.2°C
Safety: Poison by intracerebral route. Human systemic effects by subcutaneous route: kidney damage and reduced urine volume. When heated to decomposition it emits toxic fumes of I− and NOx.
PSA: 215.66000
LogP: 1.44700
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Chemistry

IUPAC Name: 3,5-Diacetamido-2,4,6-triiodobenzoic acid; (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
The MF of Meglumine diatrizoate (CAS NO.131-49-7) is C18H26I3N3O9.

                   
The MW of Meglumine diatrizoate (CAS NO.131-49-7) is 809.13.
Synonyms of Meglumine diatrizoate (CAS NO.131-49-7): Diatrizoic acid methylglucamine
Product Categories: Cell Separation (Centrifugation) Media;Hematology and Histology
Flash Point: 325.2 °C
Boiling Point: 614.1 °C
EINECS: 205-024-7

Uses

  Meglumine diatrizoate (CAS NO.131-49-7) is used as fine chemicals, pharmaceutical intermediates.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo subcutaneous 214mg/kg (214mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 392, 1969.
mouse LD50 intracrebral 80mg/kg (80mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Therapie. Vol. 26, Pg. 595, 1971.
mouse LD50 intravenous 21200mg/kg (21200mg/kg)   Drugs in Japan Vol. 6, Pg. 32, 1982.
rat LD50 intravenous 14565mg/kg (14565mg/kg)   AJR, American Journal of Roentgenology. Vol. 142, Pg. 619, 1984.
rat LD50 parenteral 44504mg/kg (44504mg/kg)   AJR, American Journal of Roentgenology. Vol. 142, Pg. 619, 1984.
rat LD50 unreported 19500mg/kg (19500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 921, 1984

Safety Profile

Poison by intracerebral route. Human systemic effects by subcutaneous route: kidney damage and reduced urine volume. When heated to decomposition it emits toxic fumes of I− and NOx.