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CAS No.: | 1334321-39-9 |
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Name: | (R)-N-Boc-3-hydroxyadaMantylglycine |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C17H27NO5 |
Molecular Weight: | 325.405 |
Synonyms: | (R)-N-Boc-2-(3-hydroxyadamant-1-yl)glycine;(alphaR)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxytricyclo[3.3.1.1(3,7)]decane-1-acetic acid; |
Density: | 1.296±0.06 g/cm3 (20 oC 760 Torr) |
Boiling Point: | 497.3±20.0 °C(Predicted) |
Solubility: | (0.27 g/L) (25 oC) |
Appearance: | White powder |
PSA: | 95.86000 |
LogP: | 2.68650 |
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Boc-3-hydroxy-1-adamantyl-L-glycine is an impurity of Saxagliptin (S143500), which is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.