CAS No.13669-70-0,3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Suppliers

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Basic Information

Molecular Structure:
CAS No.:	13669-70-0
Name:	3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
Article Data:	8

Formula:	C₁₇H₁₉NO
Molecular Weight:	253.344
Synonyms:	3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine;Fenazoxine;Nefopam;
EINECS:	237-148-2
Density:	1.064 g/cm³
Boiling Point:	369.526 °C at 760 mmHg
Flash Point:	109 °C
PSA:	12.47000
LogP:	3.17590

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Chemistry

IUPAC Name: 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine
The MF of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is C₁₇H₁₉NO.

The MW of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is 253.34.
Synonyms of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0): 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl- ; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine ; Sinalgico
Product Categories: active pharmaceutical ingredients
Apperance: white crystalline powder of its hydrochloride salt
Index of Refraction: 1.563
EINECS: 237-148-2
Density: 1.064 g/ml
Flash Point: 109 °C
Boiling Point: 369.5 °C

Uses

5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is non-narcotic analgesic drugs, both the role of muscle relaxants. Applicable to a variety of post-operative pain, cancer pain, visceral smooth muscle cramps and so on.

Production

Raw materials: Thionyl chloride-->p-Toluenesulfonic acid-->Hydrogen bromide-->Activated carbon-->Potassium borohydride-->Benzoic acid-->Benzophenone-->PARA TOLUENE-->Benzhydrol

Toxicity Data With Reference

1.	orl-wmn TDLo:15 mg/kg:CNS,CVS	BMJOAE British Medical Journal. 283 (1981),1508.
2.	orl-man TDLo:17 mg/kg:CNS,CVS	BMJOAE British Medical Journal. 283 (1981),1508.
3.	orl-rat LD50:178 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
4.	ivn-rat LD50:28 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
5.	ims-rat LD50:57 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
6.	orl-mus LD50:119 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
7.	ipr-mus LD50:50 mg/kg	DDEVD6 Drug Development and Evaluation. 3 (1979),10.
8.	ivn-mus LD50:45 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
9.	ims-mus LD50:53 mg/kg	DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
10.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, excitement, motor activity changes, increased pulse rate without blood pressure fall and heart rate changes. When heated to decomposition it emits toxic fumes of NO_x.