13669-70-0 Usage
Originator
Ajan,Kettelhack Riker,W. Germany,1976
Uses
Different sources of media describe the Uses of 13669-70-0 differently. You can refer to the following data:
1. Nefopam is a non-opioid non-steroidal centrally acting analgesic.
2. Analgesic.
Manufacturing Process
The starting material is prepared by reacting 2-benzoylbenzoic acid with
thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol)
of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml
tetrahydrofuran and then slowly added in small portions to a solution of 5.5
grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with
cooling and stirring. The mixture is then refluxed for 18 hours, cooled and
then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium
hydroxide and 16 ml water. After removal of precipitated salts by filtration, the
solution remaining is concentrated under reduced pressure and the residue
dried to yield 19.5 grams of crude product. Yield after conversion to the
hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to
133°C.5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared
as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until
all the benzene is distilled off. The residual oil is heated to 105°C and held at
this temperature for 1 hour, then cooled and dissolved in 30 ml water. This
aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide,
extracted with ether, and the extracts washed with water, dried over
anhydrous sodium sulfate and the solvent removed under reduced pressure.
The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP
238° to 242°C.
Brand name
Acupan (3M
Pharmaceuticals).
Therapeutic Function
Muscle relaxant, Antidepressant
Check Digit Verification of cas no
The CAS Registry Mumber 13669-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,6,6 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 13669-70:
(7*1)+(6*3)+(5*6)+(4*6)+(3*9)+(2*7)+(1*0)=120
120 % 10 = 0
So 13669-70-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18/h2-10,17H,11-13H2,1H3
13669-70-0Relevant articles and documents
MALODOR COUNTERACTING COMPOSITION AND AGENT AND THE USE THEREOF
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Page/Page column 22; 24-25, (2020/11/23)
The present invention relates to a malodor counteracting composition. In particular the invention relates to a malodor counteracting composition comprising nefopam, or a polymorph, a hydrate or a solvate thereof. The invention also relates to the use of said composition and attenuator or suppressor, for attenuating or suppressing malodors, in particular earthy, musty and/or moldy malodors.
A PROCESS FOR THE RESOLUTION OF NEFOPAM
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Page/Page column 3, (2008/06/13)
A process for increasing the optical purity of a mixture of enantiomers of nefopam uses a substantially single enantiomer of a O,O-diaroyltartaric acid as a resolving agent, via a bisnefopam salt of the acid. This salt is new.
Benzoxazocines: a new chemical class of centrally acting skeletal muscle relaxants.
Klohs,Draper,Petracek,Ginzel,Re
, p. 132 - 133 (2007/10/05)
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