Welcome to LookChem.com Sign In|Join Free

Products

  • or
Home > Pharmaceutical > 139220 > 

139220-18-1
Refine

Refine

Country

Business Type

Certificate

Display

Products Categories

Basic Information
CAS No.: 139220-18-1
Name: 4,12-Dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione,15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrien-1-yl]-9,11,17-trimethyl-,(3S,6Z,8E,11S,15R,17S)-
Molecular Structure:
Molecular Structure of 139220-18-1 (4,12-Dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione,15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrien-1-yl]-9,11,17-trimethyl-,(3S,6Z,8E,11S,15R,17S)-)
Formula: C31H45 N3 O4 S
Molecular Weight: 555.782
Synonyms: 4,12-Dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione,15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrienyl]-9,11,17-trimethyl-,(3S,6Z,8E,11S,15R,17S)- (9CI);4,12-Dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraene-5,13-dione,15-amino-3-[7-(dimethylamino)-2,5-dimethyl-1,3,5-heptatrienyl]-9,11,17-trimethyl-,[3S-[3R*(1E,3E,5E),6Z,8E,11R*,15S*,17R*]]-; (-)-Pateamine; (-)-Pateamine A;Pateamine; Pateamine A
PSA: 122.99000
LogP: 6.35700
Related products
Synthetic route
201339-93-7

C36H50Cl3N3O6S

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
With 10% Cd/Pd; ammonium acetate In tetrahydrofuran at 25℃; for 3.5h;78%
With ammonium acetate; 10% Cd/Pd In tetrahydrofuran at 20℃; for 5h; Hydrolysis;73%
With ammonium acetate; Cd/Pd In tetrahydrofuran at 20℃; for 3h;73%
693790-26-0

[(6Z,8E)-(3S,11S,15R,17S)-3-(tert-butyldimethylsilanyloxymethyl)-9,11,17-trimethyl-5,13-dioxo-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraen-15-yl]carbamic acid 2,2,2-trichloro-1,1-dimethyl ester

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 78 percent / TBAF / tetrahydrofuran / 20 h / 20 °C
2: 70 percent / Dess-Martin periodinane / CH2Cl2 / 3.5 h / 0 - 20 °C
3: 73 percent / benzene / 3 h / Heating
4: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
5: 73 percent / aq. NH4OAc / Cd/Pd / tetrahydrofuran / 3 h / 20 °C
View Scheme
308240-84-8

((6Z,8E)-(3S,11S,15R,17S)-3-formyl-9,11,17-trimethyl-5,13-dioxo-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraen-15-yl)carbamic acid 2,2,2-trichloro-1,1-dimethyl ester

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 73 percent / benzene / 3 h / Heating
2: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
3: 73 percent / aq. NH4OAc / Cd/Pd / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 73 percent / 3 h / Heating
2: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
3: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
4: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-96-2

((6Z,8E)-(3S,11S,15R,17S)-3-hydroxymethyl-9,11,17-trimethyl-5,13-dioxo-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraen-15-yl)carbamic acid 2,2,2-trichloro-1,1-dimethyl ester

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 70 percent / Dess-Martin periodinane / CH2Cl2 / 3.5 h / 0 - 20 °C
2: 73 percent / benzene / 3 h / Heating
3: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
4: 73 percent / aq. NH4OAc / Cd/Pd / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: 70 percent / Dess-Martin reagent; pyridine / CH2Cl2 / 2 h / 20 °C
2: 73 percent / 3 h / Heating
3: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
4: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
5: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-85-9

((6Z,8E)-(3S,11S,15R,17S)-9,11,17-trimethyl-3-((E)-2-methyl-3-oxopropenyl)-5,13-dioxo-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraen-15-yl)carbamic acid 2,2,2-trichloro-1,1-dimethyl ester

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
2: 73 percent / aq. NH4OAc / Cd/Pd / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
2: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
3: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-76-8

((6Z,8E)-(3S,11S,15R,17S)-3-((1E,3E)-4-iodo-2-methylbuta-1,3-dienyl)-9,11,17-trimethyl-5,13-dioxo-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]heneicosa-1(21),6,8,18-tetraen-15-yl)carbamic acid 2,2,2-trichloro-1,1-dimethyl ester

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / aq. NH4OAc / Cd/Pd / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
2: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-90-6

(+)-(S)-4-tert-Butyldimethylsilyloxy-3-methyl-2-butanone

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 19 steps
1.1: LiHMDS / -78 °C
1.2: 86 percent / TMSCl; Br2
2.1: 2,6-lutidene / CH2Cl2 / 12 h / 20 °C
3.1: (CF3CO)2O; pyridine / CH2Cl2 / 0.5 h / -30 °C
4.1: 92 percent / AcOH / tetrahydrofuran; H2O / 12 h / 20 °C
5.1: Et3N / CH2Cl2 / 1 h / 0 °C
6.1: dimethylsulfoxide / 6 h / 60 °C
7.1: 85 percent / DIBAL / toluene / 2 h / 0 °C
8.1: 64 percent / Ti(OEt)4 / CH2Cl2 / 4 h / 50 °C
9.1: LiHMDS / tetrahydrofuran / 0.17 h / -78 °C
10.1: 95 percent / TFA / methanol / 4 h / 20 °C
11.1: 89 percent / pyridine / CH2Cl2 / 2 h / 0 °C
12.1: 87 percent / DDQ / CH2Cl2; H2O / 2 h / 20 °C
13.1: 2,4,6-trichlorobenzoyl chloride; Et3N; DMAP / toluene / 1 h / -30 °C
13.2: Pd(dba)2; Ph3As / dimethylformamide / 1 h / 55 °C
14.1: 78 percent / TBAF / acetic acid; tetrahydrofuran / 24 h / 20 °C
15.1: 70 percent / Dess-Martin reagent; pyridine / CH2Cl2 / 2 h / 20 °C
16.1: 73 percent / 3 h / Heating
17.1: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
18.1: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
19.1: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-79-1

(S)-1-bromo-4-(tert-butyldimethylsilanyloxy)-3-methylbutan-2-one

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 18 steps
1.1: 2,6-lutidene / CH2Cl2 / 12 h / 20 °C
2.1: (CF3CO)2O; pyridine / CH2Cl2 / 0.5 h / -30 °C
3.1: 92 percent / AcOH / tetrahydrofuran; H2O / 12 h / 20 °C
4.1: Et3N / CH2Cl2 / 1 h / 0 °C
5.1: dimethylsulfoxide / 6 h / 60 °C
6.1: 85 percent / DIBAL / toluene / 2 h / 0 °C
7.1: 64 percent / Ti(OEt)4 / CH2Cl2 / 4 h / 50 °C
8.1: LiHMDS / tetrahydrofuran / 0.17 h / -78 °C
9.1: 95 percent / TFA / methanol / 4 h / 20 °C
10.1: 89 percent / pyridine / CH2Cl2 / 2 h / 0 °C
11.1: 87 percent / DDQ / CH2Cl2; H2O / 2 h / 20 °C
12.1: 2,4,6-trichlorobenzoyl chloride; Et3N; DMAP / toluene / 1 h / -30 °C
12.2: Pd(dba)2; Ph3As / dimethylformamide / 1 h / 55 °C
13.1: 78 percent / TBAF / acetic acid; tetrahydrofuran / 24 h / 20 °C
14.1: 70 percent / Dess-Martin reagent; pyridine / CH2Cl2 / 2 h / 20 °C
15.1: 73 percent / 3 h / Heating
16.1: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
17.1: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
18.1: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-93-9

(S)-3-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-butyraldehyde

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: 64 percent / Ti(OEt)4 / CH2Cl2 / 4 h / 50 °C
2.1: LiHMDS / tetrahydrofuran / 0.17 h / -78 °C
3.1: 95 percent / TFA / methanol / 4 h / 20 °C
4.1: 89 percent / pyridine / CH2Cl2 / 2 h / 0 °C
5.1: 87 percent / DDQ / CH2Cl2; H2O / 2 h / 20 °C
6.1: 2,4,6-trichlorobenzoyl chloride; Et3N; DMAP / toluene / 1 h / -30 °C
6.2: Pd(dba)2; Ph3As / dimethylformamide / 1 h / 55 °C
7.1: 78 percent / TBAF / acetic acid; tetrahydrofuran / 24 h / 20 °C
8.1: 70 percent / Dess-Martin reagent; pyridine / CH2Cl2 / 2 h / 20 °C
9.1: 73 percent / 3 h / Heating
10.1: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
11.1: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
12.1: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
308240-81-5

(S)-3-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-butyronitrile

139220-18-1

(-)-pateamine

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 85 percent / DIBAL / toluene / 2 h / 0 °C
2.1: 64 percent / Ti(OEt)4 / CH2Cl2 / 4 h / 50 °C
3.1: LiHMDS / tetrahydrofuran / 0.17 h / -78 °C
4.1: 95 percent / TFA / methanol / 4 h / 20 °C
5.1: 89 percent / pyridine / CH2Cl2 / 2 h / 0 °C
6.1: 87 percent / DDQ / CH2Cl2; H2O / 2 h / 20 °C
7.1: 2,4,6-trichlorobenzoyl chloride; Et3N; DMAP / toluene / 1 h / -30 °C
7.2: Pd(dba)2; Ph3As / dimethylformamide / 1 h / 55 °C
8.1: 78 percent / TBAF / acetic acid; tetrahydrofuran / 24 h / 20 °C
9.1: 70 percent / Dess-Martin reagent; pyridine / CH2Cl2 / 2 h / 20 °C
10.1: 73 percent / 3 h / Heating
11.1: 68 percent / CrCl2 / tetrahydrofuran / 1.5 h / 20 °C
12.1: 36 percent / Pd(CH3CN)2Cl2 / dimethylformamide / 6 h / 20 °C
13.1: 73 percent / NH4OAc / Cd-Pb / tetrahydrofuran / 5 h / 20 °C
View Scheme
Hot Products
  • Display:default sort

    New supplier

  • Pateamine A CAS 139220-18-1

  • Casno:

    139220-18-1

    Pateamine A CAS 139220-18-1

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 48.0-58.0

    Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

    Our company specializes in processing and selling chemical raw materials, chemical th Asia, Europe, America, Africa and other more than 20 countries and regions. ? Companies adheri

  •  Hebei Nengqian Chemical Import and Export Co., LTD

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 13910575315

    Address:Congtai District, La Defense North

       Inquiry Now

  • Pateamine A

  • Casno:

    139220-18-1

    Pateamine A

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Our products are mainly impurity reference and standard products for drug development。Our laboratory area is more than 5000 square meters, and our liquid phase and mass spectrometry more than 20 units。Appearance:solid Storage:short-term storage norma

    Our products are mainly impurity reference and standard products for drug development。Our laboratory area is more than 5000 square meters, and our liquid phase and mass spectrometr

  •  Hubei Moxin Biotechnology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-173-20513646

    Address:Company address: Room 005, 15th Floor, Building D2, Phase III, Software New Town, No. 8 Huacheng Avenue, East Lake High-tech Development Zone, Wuhan, Hubei Province, China

       Inquiry Now

  • Pateamine A

  • Casno:

    139220-18-1

    Pateamine A

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Chengdu Push Bio-technology Co., Ltd. provides more than 4,000 natural monomeric substances, including approximately 6,000 products at different grades, specifications and purities. We have specialized in the R&D of medicinally active ingredients sta

    We are a professional manufacturer and customizer of herbal and botanical ingredients,working with many research institutes, analytic laboratories, chemical and pharmaceutical comp

  • Chengdu Push Bio-technology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-28-85370565

    Address:No.8 Wuke West Second Road, Wuhou

       Inquiry Now

  • 139220-18-1

  • Casno:

    139220-18-1

    139220-18-1

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Supply top quality products with a reasonable price Application:api

    Hebei Ruishun Trade Co.,Ltd registered capital one million, we have a production of pharmaceutical raw materials, pharmaceutical raw materials factory reagent r&d center, we do

  • Hebei Ruishun Trade Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-311-68037669

    Address:WanDa commerce building ,yuhua district

       Inquiry Now

  • Total:22 Page 1 of 1 1
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 139220-18-1