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| CAS No.: | 1445-73-4 |
|---|---|
| Name: | 1-Methyl-4-piperidone |
| Article Data: | 27 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C6H11NO |
| Molecular Weight: | 113.159 |
| Synonyms: | 4-Piperidone,1-methyl- (6CI,7CI,8CI);1-Methyl-4-oxopiperidine;N-Methyl-4-piperidinone;NSC66491;4-Piperidinone,1-methyl-;N-Methyl-4-piperidone; |
| EINECS: | 215-895-5 |
| Density: | 0.992 g/cm3 |
| Melting Point: | 192-193 °C(Solv: ethyl acetate (141-78-6)) |
| Boiling Point: | 181.5 °C at 760 mmHg |
| Flash Point: | 60 °C |
| Solubility: | miscible with water |
| Appearance: | clear yellow to orange liquid |
| Hazard Symbols: |
 C, Xi
|
| Risk Codes: | 34-10-36/37/38 |
| Safety: | 23-24/25-37/39-26 |
| Transport Information: | UN 1224 3/PG 3 |
| PSA: | 20.31000 |
| LogP: | 0.21900 |
- 144574-27-6Oxirane,2-[(3,4-difluorophenoxy)methyl]-, (2S)-
- 1445-75-6Phosphonic acid,P-methyl-, bis(1-methylethyl) ester
- 14457-87-5Cerium bromide (CeBr3)
- 1445-79-0Gallium, trimethyl-
- 144584-29-23-Bromo-2-chloro-4-methoxypyridine
- 144584-65-6Benzene,1-bromo-3-chloro-2-fluoro-
- 144584-66-71,3-Benzodioxole,4-bromo-2,2-difluoro-
- 144584-67-8Benzene,1-bromo-2-fluoro-3-(trifluoromethyl)-
- 1445-91-6Benzenemethanol, a-methyl-, (aS)-
- 14459-29-121H,23H-Porphine-2,18-dipropanoicacid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-
| Conditions | Yield |
|---|---|
| With dmap; [2,2]bipyridinyl; 2-azatricyclo[3.3.1.13,7]dec-2-yloxidanyl; copper(l) chloride In acetonitrile at 20℃; for 3h; Reagent/catalyst; Solvent; Temperature; Time; chemoselective reaction; | 96% |
| With di-μ-chlorotetrakys-[(RP)-tert-butylphenylphosphinito-κ-P]diplatinate(2-); methyl vinyl ketone; sodium hydroxide In water; toluene for 16h; Schlenk technique; Inert atmosphere; Heating; | 14% |
| Conditions | Yield |
|---|---|
| Stage #1: methylamine; benzene With formaldehyd; toluene-4-sulfonic acid; diethyl 1,3-acetonedicarboxylate Reflux; Stage #2: With hydrogenchloride In water for 4h; Time; | 91.7% |
- 13221-89-1, 56026-45-0
1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester
- 1445-73-4
1-Methyl-4-piperidone
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water |
- 25012-72-0
ethyl 1-methyl-4-oxo-piperidin-3-carboxylate
- 1445-73-4
1-Methyl-4-piperidone
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water |
| Conditions | Yield |
|---|---|
| With ethanol; water; sodium carbonate |
| Conditions | Yield |
|---|---|
| Product distribution; equilibrium, determination by 13C NMR; |
- 142080-50-0
2-(1-Methyl-piperidin-4-ylideneamino)-propionamide
A
- 1445-73-4
1-Methyl-4-piperidone
B
- 4726-84-5
alanine amide
| Conditions | Yield |
|---|---|
| With sodium hydroxide In acetonitrile at 34℃; Rate constant; var. temp.; |
- 1445-73-4
1-Methyl-4-piperidone
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water |
- 1445-73-4
1-Methyl-4-piperidone
| Conditions | Yield |
|---|---|
| With potassium permanganate; sulfuric acid; water |
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Chemistry
Molecular Structure of N-Methyl-4-piperidone (CAS NO.1445-73-4):
.jpg)
IUPAC Name: 1-Methylpiperidin-4-one
Canonical SMILES: CN1CCC(=O)CC1
InChI: InChI=1S/C6H11NO/c1-7-4-2-6(8)3-5-7/h2-5H2,1H3
InChIKey: HUUPVABNAQUEJW-UHFFFAOYSA-N
Molecular Weight: 113.15764 [g/mol]
Molecular Formula: C6H11NO
XLogP3-AA: -0.3
H-Bond Donor: 0
H-Bond Acceptor: 2
Index of Refraction: 1.464
Molar Refractivity: 31.46 cm3
Molar Volume: 114 cm3
Surface Tension: 32.4 dyne/cm
Density: 0.992 g/cm3
Flash Point: 60 °C
Enthalpy of Vaporization: 41.77 kJ/mol
Boiling Point: 181.5 °C at 760 mmHg
Vapour Pressure: 0.85 mmHg at 25 °C
Appearance: clear yellow to orange liquid
storage temp.: 0-6 °C
Water Solubility: MISCIBLE
EINECS: 215-895-5
Product Categories: PHARMACEUTICAL INTERMEDIATES; Amines and Anilines; Carbonyl Compounds; Miscellaneous; Piperidines, Piperidones, Piperazines; Piperidine; Building Blocks; Heterocyclic Building Blocks; Piperidones
Safety Profile
Safety Information of N-Methyl-4-piperidone (CAS NO.1445-73-4):
Hazard Codes: 
C,
Xi
Risk Statements: 34-10-36/37/38
R34:Causes burns.
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-37/39-26
S24/25:Avoid contact with skin and eyes.
S23:Do not breathe vapour.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1224 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3
Specification
N-Methyl-4-piperidone (CAS NO.1445-73-4), its Synonyms are 4-Piperidinone,1-methyl- ; 1-Methyltetrahydropyridin-4(1H)-one- ; N-Methyl-4-piperidone ; 4-Piperidone,1-methyl- (6CI,7CI,8CI) .