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1598383-40-4

Basic Information
CAS No.: 1598383-40-4
Name: EPZ011969
Article Data: 2
Molecular Structure:
Molecular Structure of 1598383-40-4 (EPZ011969)
Formula: C35H51N5O4
Molecular Weight: 605.821
Synonyms: EPZ011969;EPZ011989;N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl[trans-4-[(2-methoxyethyl)methylamino]cyclohexyl]amino]-2-methyl-5-[3-(4-morpholinyl)-1-propyn-1-yl]benzamide
EINECS: -0
Density: 1.17±0.1 g/cm3(Predicted)
Boiling Point: 756.7±60.0 °C(Predicted)
PSA: 90.14000
LogP: 3.95830
Synthetic route
771579-27-2

3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

1598383-58-4

C27H41N3O4

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Stage #1: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C27H41N3O4 With triethylamine In dimethyl sulfoxide at 20℃; for 0.25h;
Stage #2: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In dimethyl sulfoxide at 0 - 20℃;
55.3%
Stage #1: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C27H41N3O4 With triethylamine In dimethyl sulfoxide at 20℃; for 0.25h;
Stage #2: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In dimethyl sulfoxide at 0 - 20℃;
55.3%
1403258-27-4

methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C
1.2: 0 - 20 °C
2.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
4.1: 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C
6.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
6.2: 0 - 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 0.33 h / 0 °C
1.2: 0 - 20 °C
2.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
4.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
5.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
6.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
6.2: 0 - 20 °C
View Scheme
1598383-48-2

methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)(methyl)amino)cyclohexyl)(ethyl)amino)-2-methylbenzoate

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
2.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
3.1: 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C
5.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
5.2: 0 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
2.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
3.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
4.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
5.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
5.2: 0 - 20 °C
View Scheme
1598383-55-1

methyl 5-bromo-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methylbenzoate

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
2.1: 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
3.1: sodium hydroxide; water / ethanol / 1 h / 60 °C
4.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
4.2: 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
2.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
3.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
4.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
4.2: 0 - 20 °C
View Scheme
5799-76-8

N-propargylmorpholine

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
2.1: sodium hydroxide; water / ethanol / 1 h / 60 °C
3.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
3.2: 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
2.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
3.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
3.2: 0 - 20 °C
View Scheme
1598383-56-2

methyl 5-bromo-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methylbenzoate

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 5-((1-(tert-butoxycarbonyl)piperidin-4-yl)ethynyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoic acid; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
2.1: sodium hydroxide; water / ethanol / 1 h / 60 °C
3.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
3.2: 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
2.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
3.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
3.2: 0 - 20 °C
View Scheme
1598383-57-3

methyl 3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzoate

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / ethanol / 1 h / 60 °C
2.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
2.2: 0 - 20 °C
View Scheme
1000342-11-9

2-methyl-3-amino-5-bromobenzoic acid methyl ester

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: acetic acid / dichloromethane / 0.33 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: acetic acid / dichloromethane / 0.33 h / 20 °C
2.2: 16 h / 0 - 20 °C
3.1: N,N-dimethyl-formamide / 0.33 h / 0 °C
3.2: 0 - 20 °C
4.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
5.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
6.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
7.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
8.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
8.2: 0 - 20 °C
View Scheme
179321-49-4

N-(tert-butoxycarbonyl)-4-aminocyclohexanone

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: acetic acid / dichloromethane / 0.33 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: acetic acid / dichloromethane / 0.33 h / 20 °C
2.2: 16 h / 0 - 20 °C
3.1: N,N-dimethyl-formamide / 0.33 h / 0 °C
3.2: 0 - 20 °C
4.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
5.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
6.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
7.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
8.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
8.2: 0 - 20 °C
View Scheme
1403258-26-3

methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-amino)-2-methylbenzoate

1598383-40-4

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: acetic acid / dichloromethane / 0.33 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: N,N-dimethyl-formamide / 0.33 h / 0 °C
2.2: 0 - 20 °C
3.1: hydrogenchloride / methanol / 2 h / 0 - 20 °C
4.1: potassium carbonate; potassium iodide / acetonitrile / 16 h / 65 °C
5.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 105 °C / Inert atmosphere
6.1: sodium hydroxide / water; ethanol / 1 h / 60 °C
7.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C
7.2: 0 - 20 °C
View Scheme
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    EPZ011969

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    EPZ011969

    Min.Order: 0

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     China (Mainland)  |  Contact Details

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  • EPZ011969

  • Casno:

    1598383-40-4

    EPZ011969

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-13437180835

    Address:Experimental Building 311-15, Nuclear Magnetic Spectrometer Industry Base, No. 128 Guanggu 7th Road, Donghu New Technology Development Zone, Wuhan (Wuhan Area, Free Trade Zone)

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    EPZ011969

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    China (Mainland)  |  Contact Details

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  • Casno:

    1598383-40-4

    EPZ011989

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  • EPZ011989

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    1598383-40-4

    EPZ011989

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    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8618874586545

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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  • EPZ011989 CAS No.1598383-40-4

  • Casno:

    1598383-40-4

    EPZ011989 CAS No.1598383-40-4

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    Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

    Guangdong Juda Chemical Industrial Co.,Limited is a company specializing in APIs,pharmaceutical intermediates, electronic chemicals, plant extracts,fine chemicals and cosmetics raw

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    China (Mainland)  |  Contact Details

    Business Type:Trading Company

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    1598383-40-4

    EPZ011969

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    best seller Application:API

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     China (Mainland)  |  Contact Details

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  • EPZ011969

  • Casno:

    1598383-40-4

    EPZ011969

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    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Henan Kanbei Chemical Co., Ltd. is a modern high-tech chemical enterprise integrating R&D, production and sales. The company has strong technical strength, advanced equipment, stri

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    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-152-37804566

    Address:Evergrande Future City, intersection of Zhengkai Avenue and Sixteenth Street, Kaifeng Area, Henan Pilot Free Trade Zone

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  • Casno:

    1598383-40-4

    EPZ011969

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    1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

    Hebei Quanhe Biotechnology Co. LTD. is an enterprise specializing in the research and development, production and trade of pharmaceutical intermediates, apis and chemical raw mater

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    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-0319-5919066

    Address:Haida Business Center, Xiangdu District

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  • EPZ011969

  • Casno:

    1598383-40-4

    EPZ011969

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    Taixing Hehao Chemical Materials Co.,Ltd, loacted in national level development zone--Jiangsu Economy Chemical park which is the leading manufacturer of new materials with science

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:15261059908

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  • EPZ011989

  • Casno:

    1598383-40-4

    EPZ011989

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    China (Mainland)  |  Contact Details

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    1598383-40-4

    EPZ011989

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    BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

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    United States  |  Contact Details

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    EPZ011969

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-18961100976

    Address:No. 271 Building B, No. 98 Ximen Da Jie, Jintan District,Changzhou city,Jiangsu,China.

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    1598383-40-4

    EPZ011989

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    Shanghai Yuanye Bio-Technology Co., Ltd. is a comprehensive enterprise of life science, specializing in the research, development and sales of biochemical reagents, analytical stan

  •  Shanghai Yuanye Bio-Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-21-61845781

    Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China

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  • EPZ011989

  • Casno:

    1598383-40-4

    EPZ011989

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    Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

    SaiWanTe (Shanghai) New Material Technology Co.,Ltd , located in shanghai ,China. It is specialized in the R&D, production and sales of chemical raw matereials, cosmetic additives,

  •  Saiwante (shanghai) New Material Technology Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:17733953109

    Address:3/F AND 4/F NO.1 LANE 65 HUANLONG RD.CHINA(SHANGHAI) PILOT FREE TRADE ZONE

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  • Casno:

    1598383-40-4

    EPZ011989

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    EPZ011989 Application:EPZ011989 is a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <3 nM. Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL/FCL for large amo

    Hunan Runhui Chem Co., Ltd. is a comprehensive Fine chemicals and Pharmaceuticals Intermediates supplier in China , Established in Changsha City of Hunan province registered capit

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-731-85570686

    Address:29 Floor,Changsheng Upper Strata,Furong District,China

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  • EPZ011969

  • Casno:

    1598383-40-4

    EPZ011969

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    best seller Application:API

    Hebei Muhuang Technology Co., Ltd was established in 2023. Although we are a very young company, our leaders have been working in the chemical industry for 20 years. We believe tha

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8618332173750,+8613191862208

    Address:石家庄桥西区仁和嘉园3号楼1单元702

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  • Casno:

    1598383-40-4

    EPZ011969

    Min.Order: 0

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    factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

    Zhejiang Jiuzhou Chemical Co.,Ltd is a market-oriented and innovation-driven biopharmaceutical company. The company is focusing on the R&D, manufacturing and sales of pharmaceutica

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    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 19334956669

    Address:Waisha Road,Jiaojiang

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  • EPZ011989

  • Casno:

    1598383-40-4

    EPZ011989

    Min.Order: 5 Milligram

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    EPZ011989 is a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <3 nM. Application:EPZ011989 is a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <3 nM.

    Our company is the biggest coal tar processing company in China with annual production capacity over 600,000 MT. The products include Wash oil, Fluorene, Quinoline, Isoquinoline, N

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    China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-61212663

    Address:huanghua

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  • EPZ011989

  • Casno:

    1598383-40-4

    EPZ011989

    Min.Order: 10 Milligram

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    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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  • EPZ011989with factory price

  • Casno:

    1598383-40-4

    EPZ011989with factory price

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    Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization. Company has strong ability of research and development

    Wuhan Sun-shine Bio-technology Corporation Limited (Shanghai Sun-shine Chemical Technology Corporation Limited) is a high-tech enterprise engaged inR&D and sales of related compoun

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+862765522452

    Address:武汉市东湖高新区高新二路388号生物医药加速器16栋501

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